5,7,4'-trihydroxy-8-methoxyflavone
5,7,4'-trihydroxy-8-methoxyflavone Basic information
- Product Name:
- 5,7,4'-trihydroxy-8-methoxyflavone
- Synonyms:
-
- 5,7,4'-trihydroxy-8-methoxyflavone
- 4'-Hydroxywogonin
- -Hydroxywogonin
- 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-methoxy-
- 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-methoxychromen-4-one
- CAS:
- 57096-02-3
- MF:
- C16H12O6
- MW:
- 300.26
- EINECS:
- 2017-001-1
- Mol File:
- 57096-02-3.mol
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5,7,4'-trihydroxy-8-methoxyflavone Chemical Properties
- Melting point:
- 303-305 °C(Solv: chloroform (67-66-3); methanol (67-56-1))
- Boiling point:
- 578.1±50.0 °C(Predicted)
- Density
- 1.512±0.06 g/cm3(Predicted)
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- powder
- pka
- 6.84±0.40(Predicted)
- color
- Yellow
- InChI
- InChI=1S/C16H12O6/c1-21-15-12(20)6-10(18)14-11(19)7-13(22-16(14)15)8-2-4-9(17)5-3-8/h2-7,17-18,20H,1H3
- InChIKey
- OEZZJTAJYYSQKM-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=C(O)C=C2)OC2=C(OC)C(O)=CC(O)=C2C(=O)C=1
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5,7,4'-trihydroxy-8-methoxyflavone Usage And Synthesis
Uses
4''-Hydroxywogonin can be used as an antiviral drug screening for COVID-19 therapy.
in vivo
4′-Hydroxywogonin (10 and 20 mg/kg; i.p.; male C57BL/6 mice) alleviates LPS-induced acute lung injury (ALI) in a mouse model[1].
| Animal Model: | Male C57BL/6 mice (6-8 weeks old; 20 g) with acute lung injury model[1] |
| Dosage: | 10 and 20 mg/kg |
| Administration: | Intraperitoneal injection, 12 and 1 h before LPS treatment |
| Result: | Had potential protective effects against inflammation in LPS induced ALI mice. Attenuated the degree of leukocyte infiltration. |
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