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crebanine

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crebanine Basic information

Product Name:
crebanine
Synonyms:
  • crebanine
  • Crebanin
  • 5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7a,8-tetrahydro-9,10-dimethoxy-7-methyl-, (7R)-
  • (R)-9,10-dimethoxy-7-methyl-6,7,7a,8-tetrahydro-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]benzo[g]quinoline
CAS:
25127-29-1
MF:
C20H21NO4
MW:
339.39
EINECS:
200-258-5
Mol File:
25127-29-1.mol
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crebanine Chemical Properties

Melting point:
126 °C
Boiling point:
488.2±45.0 °C(Predicted)
Density 
1.266±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Cryst.
pka
6?+-.0.20(Predicted)
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Safety Information

Toxicity
mouse,LD50,intraperitoneal,24230ug/kg (24.23mg/kg),BEHAVIORAL: IRRITABILITYBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDLUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION,Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 20, Pg. 422, 1989.
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crebanine Usage And Synthesis

Uses

Crebanine is an aporphine alkaloid which helps sensitize TNF-α induced apoptosis and suppress human lung adenocarcinoma. Known to exhibit anticancer properties.

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