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crebanine

Basic information Safety Supplier Related

crebanine Basic information

Product Name:
crebanine
Synonyms:
  • crebanine
  • Crebanin
  • 5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7a,8-tetrahydro-9,10-dimethoxy-7-methyl-, (7R)-
  • (R)-9,10-dimethoxy-7-methyl-6,7,7a,8-tetrahydro-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]benzo[g]quinoline
CAS:
25127-29-1
MF:
C20H21NO4
MW:
339.39
EINECS:
200-258-5
Mol File:
25127-29-1.mol
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crebanine Chemical Properties

Melting point:
126 °C
Boiling point:
488.2±45.0 °C(Predicted)
Density 
1.266±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Cryst.
pka
6?+-.0.20(Predicted)
color 
Off-white to light yellow
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Safety Information

Toxicity
mouse,LD50,intraperitoneal,24230ug/kg (24.23mg/kg),BEHAVIORAL: IRRITABILITYBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDLUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION,Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 20, Pg. 422, 1989.
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crebanine Usage And Synthesis

Chemical Properties

Milky white crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from dibutyl phthalate.

Uses

Crebanine is an aporphine alkaloid which helps sensitize TNF-α induced apoptosis and suppress human lung adenocarcinoma. Known to exhibit anticancer properties.

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