Zanamivir Amine Chemical Properties

Boiling point:

734.5±60.0 °C(Predicted)

Density 

1.53±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Methanol (Slightly), Water (Slightly)

form 

Solid

pka

3.42±0.60(Predicted)

color 

White to Off-White

Stability:

Hygroscopic

Zanamivir Amine Usage And Synthesis

Chemical Properties

White Solid

Uses

Zanamivir Amine is a synthetic precursor of Zanamivir. Relenza (zanamivir) is a medication used to treat and prevent influenza caused by influenza A and influenza B viruses.

Biological Activity

Zanamivir amine is a neuraminidase inhibitor with antiviral activity. Zanamivir amine can effectively inhibit the proliferation of influenza virus. Zanamivir amine is clinically used to inhibit influenza infection. Zanamivir amine reduces viral load by interfering with the viral replication process.

References

[1] DENNIS SCHADE . Zanamivir Amidoxime- and N-Hydroxyguanidine-Based Prodrug Approaches to Tackle Poor Oral Bioavailability[J]. Journal of pharmaceutical sciences, 2015, 104 9: Pages 3208-3219. DOI:10.1002/jps.24508.

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