ChemicalBook > Product Catalog > Analytical Chemistry > Standard > Pharmaceutical Impurity Reference Standards > ONO EI-601
ONO EI-601
ONO EI-601 Basic information
- Product Name:
- ONO EI-601
- Synonyms:
-
- ONO EI-601
- Glycine, N-[2-[[(4-hydroxyphenyl)sulfonyl]amino]benzoyl]-
- Sivelestat Impurity 2
- N-(2-(p-Hydroxyphenylsulfonylamino)benzoyl)glycine
- (2-((4-hydroxyphenyl)sulfonamido)benzoyl)glycine
- Sivelestat sodium Impurity 3
- Severlastat Impurity 2
- Severus Impurity 3
- CAS:
- 155023-59-9
- MF:
- C15H14N2O6S
- MW:
- 350.35
- Mol File:
- 155023-59-9.mol
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ONO EI-601 Usage And Synthesis
Description
Ono EI-601 is the main metabolite of the human neutrophil elastase inhibitor ONO-5046. In plasma and urine by direct injection column-switching HPLC proved to be useful for pharmacokinetic, toxicological and clinical studies.
Uses
ONO-EI-601 is the major metabolite of human neutrophil elastase inhibitor ONO-5046. ONO-5046 has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1].
References
[1] Shintani T, et al. Simultaneous determination of human neutrophil elastase inhibitor (ONO-5046) and its metabolite in plasma and urine by direct injection column-switching HPLC. J Pharm Biomed Anal. 1994 Mar;12(3):397-405. DOI:10.1016/0731-7085(94)90017-5
ONO EI-601Supplier
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