4-Hydroxyphenylpyruvic acid Chemical Properties

Melting point:

219-220 °C (dec.) (lit.)

Boiling point:

272.96°C (rough estimate)

Density 

1.2933 (rough estimate)

refractive index 

1.4500 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

ethanol: soluble50mg/mL

form 

crystalline

pka

2.50±0.54(Predicted)

color 

off-white to tan

Water Solubility 

slightly soluble

BRN 

2691632

Stability:

Hygroscopic

CAS DataBase Reference

156-39-8(CAS DataBase Reference)

NIST Chemistry Reference

Benzenepropanoic acid, 4-hydroxy-«alpha»-oxo-(156-39-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

RTECS 

UZ1000000

HS Code 

29189900

MSDS

• Language:English Provider:3-(4-Hydroxyphenyl)-2-oxopropanoic acid
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

4-Hydroxyphenylpyruvic acid Usage And Synthesis

Chemical Properties

grey to orange-brown powder

Uses

4-Hydroxyphenylpyruvic Acid is general organic reagent used in the synthesis of latifolicinin A analogs as inhibitors of breast cancer. Also used in the preparation of amperometric biosensors for β-triketone herbicides based on hydroxyphenylpyruvate.

Definition

ChEBI: An oxo carboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.

General Description

4-hydroxyphenylpyruvic acid can be determined in pork meat and Iberian ham samples by a sensitive method of multiple reaction monitoring (MRM) by mass spectrometry.

Purification Methods

p-Hydroxyphenylpyruvic acid [156-39-8] M 180.2, m 220o(dec), pKEst ~2.3. Crystallise it three times from 0.1M HCl/EtOH (4:1, v/v) immediately before use [Rose & Powell Biochem J 87 541 1963], or from Et2O. The 3,4-dinitrophenylhydrazone has m 178o. [Beilstein 10 IV 3630.]

4-Hydroxyphenylpyruvic acid(156-39-8)Related Product Information

• Calcium pyruvate
• PYRUVATE DEHYDROGENASE
• Phosphoenolpyruvate carboxylase
• EC 2.7.1.40
• Pyruvic acid
• Phenylacetone
• 3,4-Dihydroxyphenylpyruvic acid
• trans-Cinnamic acid
• Cinnamic acid
• Coumalic acid
• 3-(4-Hydroxyphenyl)propionic acid
• 3-Phenylpyruvic acid
• 4'-Hydroxypropiophenone
• 3-Methoxy-4-hydroxyphenylpyruvic acid
• 3,5-DIIODO-4-HYDROXYPHENYLPYRUVIC ACID
• 3-(4-METHOXY-PHENYL)-2,3-DIOXO-PROPIONIC ACID TERT-BUTYL ESTER
• 4-Benzyloxy-3-methoxy-6-nitrophenylpyruvic Acid
• (3,4-DIMETHOXYPHENYL)PYRUVIC ACID