1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone Chemical Properties

storage temp. 

2-8°C

solubility 

DMSO: soluble20mg/mL, clear

form 

powder

color 

white to beige

Safety Information

WGK Germany 

3

1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone Usage And Synthesis

Uses

DIF-1 is a cell growth suppressor that promotes differentiation in HL-60 cells.

Definition

ChEBI: A differentiation-inducing factor that is hexaphenone bearing two chloro substituents at positions 3 and 5, two hydroxy substituents at positions 2 and 6 as well as a single methoxy substituent at position 4. A secreted, chlorinated molecule that controls ell fate during development of Dictyostelium cells.

Biological Activity

DIF-1 (differentiation-inducing factor-1) is isolated from a Dictyostelium slime mold, and is used to inhibit proliferation/promote differentiation in various cell lines.', 'DIF-1 is a cell differentiation inducing factor.
Differentiation-inducing factor-1 (DIF-1) blocks the migration and invasion of cells and decreases the expression of matrix metalloproteinase-2. It prevents the proliferation of cells using glycogen synthase kinase-3 (GSK-3)-dependent mechanism. DIF-1 is more active when compared to DIF-2 in promoting stalk cell differentiation under submerged assay conditions.

1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone(111050-72-7)Related Product Information

• 4-(Hydroxyphenyl)-1-heptanone
• 3-CHLORO-4-METHOXYBENZALDEHYDE
• 4-Hexanoylresorcinol
• 4,6-DICHLORORESORCINOL
• 4-Hexylresorcinol
• 3',5'-DICHLORO-2'-HYDROXYACETOPHENONE
• 3-CHLORO-4-METHOXYACETOPHENONE
• 2-Chlororesorcinol
• 1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE
• 3,5-DICHLOROSALICYLALDEHYDE
• 1-(3-CHLORO-4-HYDROXYPHENYL)-1-ETHANONE
• 2-CHLORO-3-METHOXYPHENOL
• 1-(3,5-DICHLORO-2-HYDROXYPHENYL)PROPAN-1-ONE
• 3',5'-DICHLORO-4'-HYDROXYACETOPHENONE
• 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
• SALOR-INT L498912-1EA
• 3,5-DICHLORO-4-HYDROXYBENZALDEHYDE
• DIF-3