ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Chemical Properties

storage temp. 

-20°C

form 

White powder

color 

White to off-white

biological source

bacterial (corynebacterium sp)

Water Solubility 

water: 50mg/mL

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Usage And Synthesis

Uses

Adenosine 5′-triphosphate, periodate oxidized sodium salt has been used:

• as an antagonist of the purinergic receptor, P2 × 7 to inhibit P2 × 7 pathway
• as a nonspecific agonist to assess the activity of P2×₇-R by the mobilization of Ca²⁺
• to evaluate the physiological significance of elevated intracellular ATP levels
• increased?P2rx7?expression for osteoclastogenesis in?Flcn-deficient cells

General Description

A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X₇ purinergic receptors in J774 mouse macrophages. Does not affect P2_γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X₇ receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca²⁺ influx in lymphocytes (?100 μM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.

Biochem/physiol Actions

Reversible: no

in vivo

IC 50

NLRP3 inflammasome; P2X7 Receptor

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