COENZYME Q9 Chemical Properties

Melting point:

41-43°C

Boiling point:

826.8±65.0 °C(Predicted)

Density 

0.97±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated)

color 

Yellow to Orange

BRN 

1900081

Stability:

Light Sensitive

Safety Information

Safety Statements 

22-24/25

WGK Germany 

2

RTECS 

DK4786000

F 

8-10

HS Code 

29146990

Toxicity

LD50 oral in rat: > 4gm/kg

MSDS

• Language:English Provider:SigmaAldrich

COENZYME Q9 Usage And Synthesis

Chemical Properties

Bright Yellow Solid

Uses

Antibacterial and antioxidant for preventing and treating cancer.

Uses

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. Ubidecarenone impurity D may be used as an internal standard for the determination of the ubiquinol-10 in biological samples by high performance chromatography method(HPLC) and liquid chromatography tandem mass spectrometry to evaluate the oxidative stress.

Uses

Coenzyme Q₉ has been used to investigate its interference in the detection of coenzyme Q₁₀ (CoQ₁₀) by fluorescent spectrophotometer (FS-ECA). It has also been used as an analyte in chromatographic analysis of different biological samples that correspond to different genetic conditions.

Definition

ChEBI: Ubiquinone-9 is a member of ubiquinones. It has a role as an antioxidant and a human metabolite.

General Description

Coenzyme Q9 (Ubiquinone-9; Ubi-9) is a 9 isoprenyl group member of a family of ubiquinones that share a quinine chemical group but differ in the number of isoprenyl chemical subunits in their tail. The CoQ compounds are lipid soluble components of cell membranes.

Biochem/physiol Actions

The coenzyme Q (CoQ) can perform multiple functions such as electron and proton transport. CoQ9 performs similar functions to CoQ10 as the native CoQ in Caenorhabditis elegans. CoQ9 as well as other CoQ molecules may have an impact on cell life-span and these molecules are seeing increase usage in such studies.

Purification Methods

The yellow crystals are purified by recrystallisation from pet ether and by chromatography on SiO2 plates and eluted with Et2O/hexane. The purity can be checked by HPLC (silica column using 7% Et2O/hexane). It has max 270nm ( 14,850) in pet ether. [NMR and MS: Naruta J Org Chem 45 4097 1980, Le et al. Biochem Biophys Acta 32 497 1958, cf Morton Biochemical Spectroscopy (Adam Hilger, London, 1975) p 491, IR: Lester et al. Biochim Biophys Acta 33 169 1959, UV: Rüegg et al. Helv Chim Acta 42 2616 1959, Shunk J Am Chem Soc 81 5000 1959, Beilstein 8 IV 3313.]

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