Basic information Application Safety Supplier Related

2-Aminobenzylchloride

Basic information Application Safety Supplier Related

2-Aminobenzylchloride Basic information

Product Name:
2-Aminobenzylchloride
Synonyms:
  • 2-Aminobenzylchloride
  • Benzenamine, 2-(chloromethyl)-
  • Bromhexine Impurity 88
CAS:
114059-99-3
MF:
C7H8ClN
MW:
141.6
Mol File:
114059-99-3.mol
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2-Aminobenzylchloride Usage And Synthesis

Application

2-Aminobenzyl chloride can undergo a 1,4 elimination reaction to form Aza-ortho-xylylenes. For example, compound (1-80) under the conditions of 22Cs2CO3/CH2Cl2 undergoes a 1,4 elimination to remove one molecule of HCl to form Aza-ortho-xylylenes. Then, under basic conditions, the configuration changes, and an intramolecular Diels-Alder reaction occurs, giving compound (1-81) in a very high yield with an ee value of 99%.

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