Norethandrolone Chemical Properties

Melting point:

130-136°C

Boiling point:

383.47°C (rough estimate)

Density 

1.0434 (rough estimate)

refractive index 

1.4980 (estimate)

storage temp. 

-20°C

solubility 

Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml

form 

A crystalline solid

pka

15.13±0.40(Predicted)

CAS DataBase Reference

52-78-8(CAS DataBase Reference)

NIST Chemistry Reference

Norethandrolone(52-78-8)

Safety Information

Hazard Codes 

F,T

Risk Statements 

60-61-11-19-38

Safety Statements 

53-45

Norethandrolone Usage And Synthesis

Chemical Properties

mp 130-136oC

Originator

Nilevar,Searle,US,1956

Uses

Norethandrolone is antinauseant and antiemetic highly specific and selective serotonin subtype 3 (5-HT3) receptor antagonist

Uses

Controlled substance (anabolic steroid). Androgen.

Definition

ChEBI: Norethandrolone is a corticosteroid hormone.

Manufacturing Process

Through a mixture of 11 parts of charcoal containing 5% palladium and 2,000 parts of dioxane a stream of hydrogen is passed for 60 minutes. Then 86 parts of 17-ethynyl-19-nortestosterone (Norethindrone) in 1,500 parts of dioxane are added and the mixture is hydrogenated until 2 mols of hydrogen are absorbed. The catalyst is then removed by filtration and the solvent is evaporated under vacuum. The crystalline residue is dissolved in 2,700 parts of benzene and thus applied to a chromatography column containing 5,000 parts of silica gel. The column is washed with 2,700 parts of benzene, 4,500 parts of a 10% solution of ethyl acetate in benzene and 27,000 parts of a 20% solution of ethyl acetate in benzene and is then eluted with 30,000 parts of a 30% solution of ethyl acetate in benzene. The resulting eluate is concentrated under vacuum and the residue is recrystallized from methanol and dried to constant weight at 75°C. The 17-ethyl-19-nortestosterone thus obtained melts at about 140°C to 141°C.

Therapeutic Function

Androgen

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