Sermorelin acetate Chemical Properties

storage temp. 

0 - 4 °C for short term, or -20 °C for long term

solubility 

Soluble in DMSO, not in water

InChIKey

WGWPRVFKDLAUQJ-PUMMXPSGNA-N

Sermorelin acetate Usage And Synthesis

Description

Sermorelin acetate, also known as INN/Geref/Gerel, is a peptide analogue of growth hormone-releasing hormone (GHRH) used as a diagnostic agent to evaluate growth hormone (GH) secretion and diagnose growth hormone deficiency. It is a 29 amino acid polypeptide representing fragments 1-29 from endogenous human GHRH and is considered to be the shortest fully functional fragment of GHRH.

Uses

Sermorelin acetate is used as a diagnostic agent to assess growth hormone (GH) secretion. It is also used as doping agent in sports due to its correlation with increased growth of muscular and skeletal tissue. Sermorelin use is also hypothesized to improve deep rapid eye movement sleep.

benefits

The benefits of using Sermorelin acetate therapy are multifaceted and include: helping to increase muscle strength, weight loss, improved bone mineral density, improved cognitive health, increased energy levels, restoration of sexual dysfunction, improvement of cardiovascular disease, enhancement of the immune system, improvement of skin health, and a boost in metabolism.

Side effects

All medicines may cause side effects, but many have no or minor side effects. The most common side effects: Facial flushing; headache; nausea; pain, redness, or swelling at the injection site; paleness; strange taste in mouth; vomiting.
The Severe side effects : Severe allergic reactions (rash, hives, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips, or tongue).

References

Influence of growth hormone (GH) and GH-releasing factor on locomotor activity in rats DOI: 10.1016/0196-9781(93)90101-L
Comparison of GH-stimulation by GH-RH(1-29)NH2 and an agmatine29 GH-RH analog, after intravenous, subcutaneous and intranasal administration and after pulmonary inhalation in rats DOI: 10.1111/j.1399-3011.1993.tb00332.x
Potent agonists of growth hormone-releasing hormone Part I DOI: 10.1111/j.1399-3011.1992.tb00791.x
Synthesis and in vitro and in vivo activity of analogs of growth hormone-releasing hormone (GH-RH) with C-terminal agmatine DOI: 10.1111/j.1399-3011.1990.tb00988.x
Growth-hormone-releasing hormone DOI: 10.1093/clinchem/36.3.415

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