koumine
koumine Basic information
- Product Name:
- koumine
- Synonyms:
-
- koumine
- (3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan
- 7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-
- 6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole, 11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-, (3S,4S,4aR,6R,11bS,11cS)-
- (3S,4S,4aR,6R,11bS,11cS)-2-Methyl-11c-vinyl-1,2,3,4,4a,5,6,11c-octahydro-6,4-(epoxymethano)-3,11b-methanopyrido[4,3-c]carbazole
- CAS:
- 1358-76-5
- MF:
- C20H22N2O
- MW:
- 306.4
- Product Categories:
-
- Alkaloids
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 1358-76-5.mol
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koumine Chemical Properties
- Melting point:
- 168℃
- Boiling point:
- 436.5±45.0 °C(Predicted)
- Density
- 1.42
- storage temp.
- 2-8°C
- solubility
- DMSO : 31.25 mg/mL (101.99 mM; Need ultrasonic)
- form
- powder
- pka
- 8.67±0.40(Predicted)
- color
- Yellow-brown
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koumine Usage And Synthesis
Description
The Chinese drug 'Kou-wen', said to be derived from Gelsemium elegans Benth., is stated to contain this alkaloid which forms rhombic prisms from Me2 CO. It has [α]23D - 265° (EtOH) and forms a crystalline hydrochloride, m.p. 255°C (dec.) and a hydrobromide, m.p. 269°C (dec.).
Occurrence
Koumine is an alkaloid isolated from Gelsemium elegans Benth.
Uses
Koumine is known to attenuate the lipopolysaccharide-stimulated inflammation in RAW264.7 macrophages.
References
Chou, Pak, Hou., Chin. 1. Physiol., 5, 345 (1931)
Chou, Wang, Chen., ibid, 8,40 (1934)
Chi, Kao, Huang., 1. Amer. Chem. Soc., 60, 1723 (1938)
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