4,6-Dichloro-2-pyridinecarboxylic acid Chemical Properties

Melting point:

111-112℃

Boiling point:

336.6±37.0 °C(Predicted)

Density 

1.612

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

2.90±0.10(Predicted)

Appearance

Off-white to light yellow Solid

InChI

InChI=1S/C6H3Cl2NO2/c7-3-1-4(6(10)11)9-5(8)2-3/h1-2H,(H,10,11)

InChIKey

AYYUSDKNXRPJBH-UHFFFAOYSA-N

SMILES

C1(C(O)=O)=NC(Cl)=CC(Cl)=C1

Safety Information

RIDADR 

UN2811

HS Code 

2933399990

4,6-Dichloro-2-pyridinecarboxylic acid Usage And Synthesis

Synthesis

Synthesis of 4,6-dichloropyridine-2-carboxylic acid [Compound (II-17)]: a mixture of ethyl 4,6-dichloropyridinecarboxylate (0.5 g, 2.43 mmol) with sodium hydroxide (0.11 g, 2.67 mmol) was stirred in 1.1 mL of water and 11 mL of ethanol and reacted for 1 hr at 60 °C. After completion of the reaction, ethanol was removed by distillation and the residue was washed with dichloromethane. The aqueous layer was acidified with dilute hydrochloric acid and extracted with ethyl acetate. The organic phase was washed with saturated brine solution and dried over anhydrous sodium sulfate. A white solid product was obtained, yield: 0.46 g, yield: 98.7%, melting point: 114-116 °C. IR (KBr, cm-1): 3562, 1692, 1557, 1395, 1287, 819.

References

[1] Patent: US6610853, 2003, B1
[2] Patent: WO2018/122775, 2018, A1. Location in patent: Page/Page column 98-99

4,6-Dichloro-2-pyridinecarboxylic acid(88912-25-8)Related Product Information

• 4,6-Dichloro-5-pyrimidinecarbaldehyde
• 5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE
• 4,6-Dichloro-2-pyridinecarboxylic acid
• Tetrachloropyridine-2-carboxylic acid
• ETHYL 3,4,5,6-TETRACHLOROPYRIDINE-2-CARBOXYLATE
• METHYL 3,4,5,6-TETRACHLOROPYRIDINE-2-CARBOXYLATE