5-Bromo-2,4-dichloropyridine Chemical Properties

Melting point:

21-22℃

Boiling point:

60-62℃ (0.9 Torr)

Density 

1.848±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

liquid

pka

-1.31±0.10(Predicted)

color 

Yellow

InChI

InChI=1S/C5H2BrCl2N/c6-3-2-9-5(8)1-4(3)7/h1-2H

InChIKey

SGCSNJNPPSSPKZ-UHFFFAOYSA-N

SMILES

C1(Cl)=NC=C(Br)C(Cl)=C1

Safety Information

HazardClass 

IRRITANT

HS Code 

2933998090

5-Bromo-2,4-dichloropyridine Usage And Synthesis

Synthesis

5-bromo-2-chloropyridine could be used as a starting material to synthesize 5-Bromo-2,4-dichloropyridine. At -100 °C, diisopropylamine (14 mL, 10 g, 0.10 mol) and 5-bromo-2-chloropyridine (19 g, 0.10 mol) were added consecutively to a solution of butyllithium (0.10 mol) in tetrahydrofuran (0.23 L) and hexanes (60 mL). After 45 min at -100 °C, the mixture was treated with 1,1,2-trichloro-1,2,2-trifluoroethane (12 mL, 19 g, 0.10 mol) and, after 45 min at -75 °C, with water (50 mL). Upon distillation, the product was collected as a colorless liquid, bp 60-62 °C/0.9 mmHg, yield 18.7 g (83%).

5-Bromo-2,4-dichloropyridine(849937-96-8)Related Product Information

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