Ammothamnine
Ammothamnine Basic information
- Product Name:
- Ammothamnine
- Synonyms:
-
- OXYMATRINE
- 1-oxide,(1-beta)-matridin-15-on
- 1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, 4-oxide, (4R,7aS,13aR,13bR,13cS)-
- Ammothamnine Oxymatrine
- Oxymatrine, 98%, from Sophora flavescens Aiton
- (4R,7aS,13aR,13bR,13cS)-dodecahydro-4-oxide-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
- Oxymatrine 16837-52-8
- matrine,1-oxide
- CAS:
- 16837-52-8
- MF:
- C15H24N2O2
- MW:
- 264.36
- EINECS:
- 605-514-4
- Product Categories:
-
- Pyrazoles
- Inhibitors
- Plant extracts
- chemical reagent
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Pharmaceutical material and intermeidates
- Alkaloids
- Natural Plant Extract
- Plant extract
- pharmaceutical intermediate
- phytochemical
- 16837-52-8
- Mol File:
- 16837-52-8.mol
Ammothamnine Chemical Properties
- Melting point:
- 208℃
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- methanol: soluble10mg/mL, clear, colorless
- pka
- 4.87±0.20(Predicted)
- form
- powder
- color
- white to off-white
- Stability:
- Hygroscopic
- InChIKey
- XVPBINOPNYFXID-LHDUFFHYSA-N
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 22-20/22
- Safety Statements
- 24/25
- WGK Germany
- 3
- RTECS
- OQ1770000
- HS Code
- 29399990
- Hazardous Substances Data
- 16837-52-8(Hazardous Substances Data)
Ammothamnine Usage And Synthesis
Description
An alkaloid from Sophora angustifolia var. flavescens S. and Z., the bas'e crystal_x0002_lizes as the monohydrate having the lower melting point given above. It is dextrorotatory with [α]19D + 47.7° (EtOH) and yields crystalline salts and derivatives: hydrobromide, m.p. 21SoC; aurichloride, m.p. 207°C (dec.); perchlorate, m.p. 240°C (dec.); picrate, m.p. 21SoC and the methochloride aurichloride, m.p. 18SoC (dec.). Ochiai and Ito have shown that it is formed by the action of hydrogen peroxide on Matrine (q.v.), indicating that its structure is matrine-N-oxide.
Description
Oxymatrine is a natural alkaloid isolated from the root of S. flavescens, an herb used in traditional Chinese herbal medicine. It has antiviral properties, inhibiting the replication of hepatitis B alone and in combination with lamivudine. Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-
Uses
Oxymatrine is a an anti-tumor agent triggering apoptosis in human leukemia cells.
Uses
antifungal, hepatoprotectant
Definition
ChEBI: Ammothamnine is an alkaloid and a tertiary amine oxide.
References
Kondo et al., Arch. Pharm., 275,493 (1937)
Ochiai, Ito., Ber., 81,938 (1938)
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Ammothamnine(16837-52-8)Related Product Information
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