(S)-2-(Aminomethyl)-1-Cbz-pyrrolidine Chemical Properties

Boiling point:

370.5±25.0 °C(Predicted)

Density 

1.155±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

pka

9.91±0.29(Predicted)

Appearance

Colorless to light yellow Liquid

CAS DataBase Reference

119020-03-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-41-37/38-22

Safety Statements 

26-36/37/39-39

(S)-2-(Aminomethyl)-1-Cbz-pyrrolidine Usage And Synthesis

Uses

(S)-Benzyl 2-(aminomethyl)pyrrolidine-1-carboxylate was a useful reagent in preparation of trifluoro-N-[(S)-pyrrolidinylmethyl]methanesulfonamide.

Synthesis

GENERAL METHOD: Under stirring conditions, azide derivatives 9a or 9b (4.03 mmol) were dissolved in THF (1 mL), followed by the addition of solid triphenylphosphine (Ph3P, 4.03 mmol) and water (H2O, 6.04 mmol). The reaction mixture was stirred continuously for 12 h at room temperature. After completion of the reaction, the solvent was removed by concentration under reduced pressure. The crude product was purified by rapid column chromatography on silica gel with the eluent being a solvent mixture of methanol-dichloromethane (9:1, v/v).

References

[1] Synthetic Communications, 2011, vol. 41, # 17, p. 2517 - 2523
[2] Synthesis (Germany), 2013, vol. 45, # 17, p. 2458 - 2468
[3] Tetrahedron Letters, 2010, vol. 51, # 1, p. 209 - 212
[4] Tetrahedron Letters, 1991, vol. 32, # 49, p. 7183 - 7186

(S)-2-(Aminomethyl)-1-Cbz-pyrrolidine(119020-03-0)Related Product Information

• Polyvinylpyrrolidone
• N-Methyl-2-pyrrolidone
• Pyrrolidine
• N-Vinyl-2-pyrrolidone
• METHYL-2-PYRROLIDONE
• Z-PRO-NH2
• Benzyl formate
• 4-(Aminomethyl)piperidine
• Z-PRO-GLY-OH
• N-CBZ-PRO-LEU-GLY HYDROXAMATE
• Z-PRO-LEU-GLY-NH2
• N2-[N-[N-[1-[[[4-(phenylazo)phenyl]methoxy]carbonyl]-L-prolyl]-L-phenylalanyl]glycyl]-D-arginine
• 4-PHENYLAZOBENZYLOXYCARBONYL-L-PRO-LEU-GLY-PRO-D-ARG DIHYDRATE
• Z-PRO-PRO-OH
• Z-PRO-PHE-OH
• Z-PRO-BETANA
• Z-PRO-LEU-OH
• Z-PRO-LEU-GLY-OET