Basic information Safety Supplier Related

benzo[d]oxazole-6-carboxylic acid

Basic information Safety Supplier Related

benzo[d]oxazole-6-carboxylic acid Basic information

Product Name:
benzo[d]oxazole-6-carboxylic acid
Synonyms:
  • benzo[d]oxazole-6-carboxylic acid
  • 1,3-Benzoxazole-6-carboxylic acid
  • 6-Benzoxazolecarboxylic acid
  • Benzoxazole-6-carboxylic Acid
  • 1,3-Benzoxazole-6-carboxylic acid 97%
  • SB9
  • Serpin B9-IN-1
  • 1,3-Benzoxazole-6-carboxylic acid, 10 mM in DMSO
CAS:
154235-77-5
MF:
C8H5NO3
MW:
163.13
Mol File:
154235-77-5.mol
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benzo[d]oxazole-6-carboxylic acid Chemical Properties

Melting point:
280-290 °C (sublm)(Press: 16 Torr)
Boiling point:
350.1±15.0 °C(Predicted)
Density 
1.455±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
Solid
pka
3.60±0.30(Predicted)
color 
Light brown to brown
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Safety Information

HS Code 
2934999090
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benzo[d]oxazole-6-carboxylic acid Usage And Synthesis

Uses

6-?Benzoxazolecarboxyli?c Acid is a reactant used in the design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists.

in vivo

Serpin B9-IN-1 (BTCA) inhibits bone metastasis (BM) in multiple tumor metastasis models. Serpin B9-IN-1 (50 mg/kg/d; ip; 14 d) effectively reduced the survival rate and metastasis proportion of metastatic cancer cells in the mouse bone metastasis model with LLC1-BM3 injected into the tail artery (CA)[1].
Serpin B9-IN-1 (300 μg/d; ip; 14 d) effectively delayed the average time to bone metastasis (BM) in the LLC1-BM3 cell group[1].

Animal Model:LLC1-BM3 Bone Metastatic Mouse Model by CA injections[1]
Dosage:50 mg/kg
Administration:ip; followed after cancer cell injection, injection daily for 14 days
Result:Reduced the survival rate and metastasis proportion of metastatic cancer cells
Animal Model:LLC1-BM3-sr-ctrl Model in Mouse[1]
Dosage:300 μg
Administration:ip; once daily for 14 days
Result:Delayed the mean time to occurrence of bone metastasis (BM), and lowered the burden of BM in LLC1-BM3-shSB9 cells group.

benzo[d]oxazole-6-carboxylic acidSupplier

Carbott PharmTech Inc.
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Shangchem Co., Ltd.
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Pure Chemistry Scientific Inc.
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Tetranov Biopharm
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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chenyj@titansci.com