TALIPEXOLE Chemical Properties

Boiling point:

364.6±37.0 °C(Predicted)

Density 

1.167±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Powder

pka

7.22±0.20(Predicted)

TALIPEXOLE Usage And Synthesis

Description

Domin was launched in Japan for Parkinson's disease. The compound is readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its antiparkinson activity resides in the fact that talipexole is a selective agonist for presynaptic dopamine D₂ receptors with no D₁ receptor activity. It is a clonidine-like α₂-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most widely used dopamine angonist. Also it is 70 times more potent than bromocriptine and has a more rapid onset of action. In addition to its anti-tremor activity there was a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT₃ receptor antagonistic activity. Its metabolites have no biological activity, there was no development of tolerence and its effect could be enhanced by L-dopa.

Originator

Boehringer Ingelheim (Germany)

Definition

ChEBI: 6-prop-2-enyl-4,5,7,8-tetrahydrothiazolo[4,5-d]azepin-2-amine is an azepine.

brand name

Domin

TALIPEXOLE(101626-70-4)Related Product Information

• ARANIDIPINE
• Bendamustine
• Donepezil
• CALYXOL
• ISO-TALIPEXOLE, DIHYDROCHLORIDE
• TALIPEXOLE DIDHYDROCHLORIDE,Talipexole, 5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride,talipexole hydrochloride
• 2-(4-METHYL-THIAZOL-5-YL)-ETHYLAMINE
• TALIPEXOLE
• 2-(THIAZOL-4-YL)ETHYLAMINE
• AMTHAMINE DIHYDROBROMIDE
• 5,6,7,8-TETRAHYDRO-4H-THIAZOLO[4,5-D]AZEPINE
• 2-(2-AMINOTHIAZOL-4-YL)ETHYLAMINE