Betaxolol hydrochloride Chemical Properties

Melting point:

116°

storage temp. 

2-8°C

solubility 

H₂O: 36 mg/mL, soluble

form 

solid

color 

white

Water Solubility 

Soluble to 50 mM in water

Merck 

14,1182

Stability:

Hygroscopic

InChI

InChI=1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H

InChIKey

CHDPSNLJFOQTRK-UHFFFAOYSA-N

SMILES

C1(OCC(O)CNC(C)C)C=CC(CCOCC2CC2)=CC=1.Cl

CAS DataBase Reference

63659-19-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

RTECS 

UA9823000

HS Code 

2922504500

Toxicity

LD50 in mice (mg/kg): 944 orally; 37 i.v. (Manoury)

MSDS

• Language:English Provider:SigmaAldrich

Betaxolol hydrochloride Usage And Synthesis

Description

Betaxolol (hydrochloride) (Item No. 26285) is an analytical reference standard categorized as a β₁-adrenergic receptor antagonist. Formulations containing β-adrenergic receptor antagonists have been used to enhance physical performance in athletes. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .

Description

Betaxolol hydrochloride is a cardioselective β-adrenergic blocker, reportedly devoid of intrinsic sympathomimetic and membrane stabilizing properties. Its long duration of action permits once-daily dosing in mild to moderate hypertension. It is also being evaluated in glaucoma.

Chemical Properties

White or almost white, crystalline powder.

Originator

Synthelabo (France)

Uses

antifungal

Uses

Betaxolol Hydrochloride, a cardioselective β1-adrenergic blocker. An antihypertensive; antiglaucoma.

Definition

ChEBI: The hydrochloride salt of betaxolol.

brand name

Betoptic (Alcon); Kerlone (Sanofi Aventis).

Biological Activity

Selective β 1 -adrenoceptor antagonist.

storage

Store at RT

References

[1] SEUNG-WOON MYUNG  Cheon H J. Gas chromatograph–mass spectrometric method for the determination of carvedilol and its metabolites in human urine[J]. Journal of Chromatography B, 2005, 822 1: Pages 70-77. DOI: 10.1016/j.jchromb.2005.05.023
[2] PANKAJ GUPTA R G. Amino Functionalized Graphene Oxide and Polymer Nanocomposite Based Electrochemical Platform for Sensitive Assay of Anti-Doping Drug Atenolol in Biological Fluids[J]. Journal of The Electrochemical Society, 2016, 163 1. DOI: 10.1149/2.0281613jes
[3] A WELLSTEIN  G G B  D Palm. Affinity and selectivity of beta-adrenoceptor antagonists in vitro.[J]. Journal of Cardiovascular Pharmacology, 1986, 8 Suppl 11: S36-40. DOI: 10.1097/00005344-198511001-00006
[4] DOROTA POZAROWSKA  Zbigniew D  Piotr Pozarowski. Cytometric assessment of cytostatic and cytotoxic effects of topical glaucoma medications on human epithelial corneal line cells?[J]. Cytometry Part B: Clinical Cytometry, 2009, 78B 2: 130-137. DOI: 10.1002/cyto.b.20493
[5] N. SHARIF. Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes.[J]. Journal of Ocular Pharmacology and Therapeutics, 2001, 26 1: 305-317. DOI: 10.1089/108076801753162726
[6] GLYN CHIDLOW  Neville N O  José Melena. Betaxolol, a β1-adrenoceptor antagonist, reduces Na+ influx into cortical synaptosomes by direct interaction with Na+ channels: comparison with other β-adrenoceptor antagonists[J]. British Journal of Pharmacology, 2009, 130 4: 759-766. DOI: 10.1038/sj.bjp.0703369

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