3-bromo-2-nitrobenzaldehyde Chemical Properties

Melting point:

75-77 °C

Boiling point:

298.7±25.0 °C(Predicted)

Density 

1.781±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

color 

Pale Yellow

Safety Information

HS Code 

2912290090

3-bromo-2-nitrobenzaldehyde Usage And Synthesis

Uses

3-Bromo-2-nitrobenzaldehyde is an intermediate in the synthesis of peptidomimetic BACE1 inhibitor.

Synthesis

General procedure for the synthesis of 3-bromo-2-nitrobenzaldehyde from 3-bromo-2-nitrobenzenemethanol: 14.0 g of 3-bromo-2-nitrobenzenemethanol and 150 mL of 1,2-dichloroethane were added to a three-necked flask, followed by 42.0 g of manganese dioxide. The mixture was heated to reflux. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated. Purification by column chromatography separation resulted in 9.4 g (67.7% yield) of 3-bromo-2-nitrobenzaldehyde.

References

[1] Patent: CN103880683, 2018, B. Location in patent: Paragraph 0024; 0033-0034; 0045

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