Fmoc-Thr-Obzl Chemical Properties

Boiling point:

656.9±55.0 °C(Predicted)

Density 

1.257±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

pka

10.34±0.46(Predicted)

InChIKey

WQYIETDVEJEHCP-OSPHWJPCSA-N

SMILES

C(OCC1=CC=CC=C1)(=O)[C@H]([C@H](O)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

Fmoc-Thr-Obzl Usage And Synthesis

Synthesis

Fmoc(OTIPS) benzyl ester (0.87 g, 1.48 mmol) is dissolved in 7.4 mL dry CH2Cl2 under an argon atmosphere. The solution is cooled to 0°C and 7.4 mL of 40% (v/v) Piperidine solution in dry CH2Cl2 is added dropwise. After 15 min of stirring at 0°C, the mixture is concentrated in vacuo at 25°C to an oil and put immediately onto the silica column (cyclohexane/EtOAc 5: 1 + 0.5% NEt3, elution of product with 1: 1 + 0.5% NEt3). The yield of Fmoc-Thr-Obzl is 0.44 g (1.20 mmol, 81%) as a colorless oil.