3,5-Dichloropyridazine Chemical Properties

Melting point:

60.0 to 64.0 °C

Boiling point:

280.8±20.0 °C(Predicted)

Density 

1.493±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO (Sparingly), Methanol (Slightly)

form 

Solid

pka

-0.25±0.10(Predicted)

color 

Yellow to Dark Orange

InChIKey

JZSAUQMXKHBZEO-UHFFFAOYSA-N

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HS Code 

29339900

3,5-Dichloropyridazine Usage And Synthesis

Chemical Properties

Yellow solid powder.

Uses

3,5-Dichloropyridazine acts as a novel histamine H4 antagonist used in the treatment of asthma and allergy. Potential for antinociceptive and antiinflammatory effects.

Uses

3,5-Dichloropyridazine used in the treatment of asthma and allergy. Potential for antinociceptive and antiinflammatory effects

Preparation

Preparation of 3,5-Dichloropyridazine:
2,4,4,4-Tetrachlorocrotonaldehyde is dissolved in a solvent, and a mixture of semicarbazide hydrochloride, water, and solvent is added dropwise under controlled temperature conditions. The reaction is stirred for 5 hours. Afterward, the reaction mixture is concentrated under reduced pressure to remove the solvent. Water is added, and the temperature is lowered to 5°C, allowing a solid to precipitate. The solid is filtered and recrystallized using a dichloromethane/petroleum ether mixture, yielding 3,5-dichloropyridazine as a white crystalline solid.

Definition

ChEBI: 3,5-Dichloropyridazine is a member of pyridazines.

3,5-Dichloropyridazine(1837-55-4)Related Product Information

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