Ethyl 2-methylthiazole-4-carboxylate Chemical Properties

Melting point:

54-58 °C

Boiling point:

242.1±13.0 °C(Predicted)

Density 

1.198±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

1.10±0.10(Predicted)

form 

solid

Appearance

Light yellow to yellow Solid

InChI

InChI=1S/C7H9NO2S/c1-3-10-7(9)6-4-11-5(2)8-6/h4H,3H2,1-2H3

InChIKey

QWWPUBQHZFHZSF-UHFFFAOYSA-N

SMILES

S1C=C(C(OCC)=O)N=C1C

CAS DataBase Reference

6436-59-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37-24/25

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29341000

MSDS

• Language:English Provider:ALFA

Ethyl 2-methylthiazole-4-carboxylate Usage And Synthesis

Chemical Properties

light yellowto brownpowde

Uses

Ethyl 2-methylthiazole-4-carboxylate is a reactant used in the synthesis of 2,?4,?5-?trisubstituted thiazoles as antituberculosis agents effective against drug resistant tuberculosis.

Synthesis

Ethyl 2-methylthiazole-4-carboxylate was synthesized from ethyl 3-bromopyruvate and thioacetamide in ethanol (EtOH) at 250 W power, 25 kHz frequency, flow rate controlled at 2 mL/min, and reaction time of 1.5 hours.

References

[1] Journal of Organic Chemistry, 1997, vol. 62, # 12, p. 3804 - 3805
[2] Organic Letters, 2008, vol. 10, # 8, p. 1565 - 1568
[3] Journal of Organic Chemistry, 2001, vol. 66, # 19, p. 6410 - 6424
[4] Angewandte Chemie - International Edition, 2008, vol. 47, # 46, p. 8950 - 8953
[5] Patent: US2010/249404, 2010, A1. Location in patent: Page/Page column 11

Ethyl 2-methylthiazole-4-carboxylate(6436-59-5)Related Product Information

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