3-N-Boc-amino-azetidine
3-N-Boc-amino-azetidine Basic information
- Product Name:
- 3-N-Boc-amino-azetidine
- Synonyms:
-
- TERT-BUTYL AZETIDIN-3-YLCARBAMATE
- AZETIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER
- 3-AMINOAZETIDINE, 3-BOC PROTECTED
- 3-BOC-AMINOAZETIDINE
- 3-N-BOC-AMINO-AZETIDINE
- Carbamic acid, 3-azetidinyl-, 1,1-dimethylethyl ester (9CI)
- 3-BOC-AMINOAZETIDINE 98%
- Azetidin-3-yl-carbamic acid tert-butyl ester HCl
- CAS:
- 91188-13-5
- MF:
- C8H16N2O2
- MW:
- 172.22
- EINECS:
- 676-108-2
- Product Categories:
-
- Ring Systems
- N-BOC
- Heterocycles series
- Azetidines
- pharmacetical
- Amines
- Azetidine
- Mol File:
- 91188-13-5.mol
3-N-Boc-amino-azetidine Chemical Properties
- Melting point:
- 63-72°C
- Boiling point:
- 268℃
- Density
- 1.06
- Flash point:
- 116°(241°F)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 12.26±0.40(Predicted)
- form
- powder
- color
- White
- Water Solubility
- Soluble in water. (5g/100ml)
- InChI
- InChI=1S/C8H16N2O2/c1-8(2,3)12-7(11)10-6-4-9-5-6/h6,9H,4-5H2,1-3H3,(H,10,11)
- InChIKey
- NEMXVXVJGXZDRR-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NC1CNC1
- CAS DataBase Reference
- 91188-13-5(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-52
- Safety Statements
- 26-36/37/39
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2933998090
3-N-Boc-amino-azetidine Usage And Synthesis
Uses
tert-Butyl N-Azetidin-3-ylcarbamate is a versatile reactant used in the preparation of substituted benzothiazoles via copper-catalyzed three-component domino condensation/S-arylation/heterocyclization reactions. Also used in the synthesis and pharmacokinetic evaluation of Et aminonicotinate sulfonylureas as antagonists of P2Y12 receptor.
Chemical Properties
white powder
Uses
It is an intermediate in organic syntheses.
Synthesis
91189-18-3
91188-13-5
General procedure for the synthesis of 3-Boc-aminoazetidine from tert-butyl (1-diphenylmethylazetidin-3-yl)carbamate: a mixture of the feedstock (113 mg, 0.33 mmol) and 10% Pd/C catalyst (88 mg) in ethanol (3 mL) was subjected to a hydrogen atmosphere and reacted with stirring at room temperature for 2 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give 3-Boc-aminoazetidine (63 mg) as a white solid.
References
[1] Patent: US2004/147502, 2004, A1. Location in patent: Page/Page column 23; 25
[2] Patent: WO2004/112793, 2004, A1. Location in patent: Page/Page column 147
3-N-Boc-amino-azetidine Preparation Products And Raw materials
Raw materials
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3-N-Boc-amino-azetidine(91188-13-5)Related Product Information
- Betaine
- 2-Butoxyethanol
- Diethylene glycol monobutyl ether
- Azetidine
- Buprofezin
- Albuterol sulfate
- ALTRENOGEST
- Salbutamol
- DOBUTAMINE
- Glycine
- Cyhalofop-butyl
- Butyl acetate
- tert-Butanol
- Butylamine
- Butyl acrylate
- 3-AMINOAZETIDINE
- (3-TERT-BUTOXYCARBONYLAMINO-AZETIDIN-1-YL)-FURAN-2-YL-ACETIC ACID
- (3-TERT-BUTOXYCARBONYLAMINO-AZETIDIN-1-YL)-M-TOLYL-ACETIC ACID