3,4-Dimethoxy-3-cyclobutene-1,2-dione Chemical Properties

Melting point:

55-57 °C (lit.)

Boiling point:

219.65°C (rough estimate)

Density 

1.3863 (rough estimate)

refractive index 

1.5800 (estimate)

storage temp. 

2-8°C

solubility 

DMSO, Methanol (Slightly)

form 

Solid

color 

Off-White to Pale Brown

Water Solubility 

Very soluble in water.

InChIKey

SZBNZTGCAMLMJY-UHFFFAOYSA-N

CAS DataBase Reference

5222-73-1(CAS DataBase Reference)

NIST Chemistry Reference

3,4-Dimethoxy-3-cyclobutene-1,2-dione(5222-73-1)

Safety Information

Risk Statements 

42/43

Safety Statements 

22-24/25-26-36/37/39

WGK Germany 

3

HS Code 

29145090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3,4-Dimethoxy-3-cyclobutene-1,2-dione Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

3,4-Dimethoxy-3-cyclobutene-1,2-dione (Dimethyl squarate) finds it uses in the synthesis of chiral squaramides, highly enantioselective catalyst for the Friedel-Crafts reactions of indoles, 3-(hydroxyamino)-4-methoxy-3-cyclobutene-1,2-dione, squarate derivatives of the O-SP-core antigens, methyl squarate derivative of the Ogawa O-SP-core antigen, o-quinodimethanes, benzocyclobutenes, quinones. It is employed as a starting material in the preparation of o-quinodimethanes, benzocyclobutenes, and quinones.

General Description

3,4-Dimethoxy-3-cyclobutene-1,2-dione (Dimethyl squarate) is a cyclobutene derivative. It reacts with hydroxylamine derivatives to afford 3-hydroxyamino-4-methoxy-3-cyclobutene-1,2-diones.

3,4-Dimethoxy-3-cyclobutene-1,2-dione(5222-73-1)Related Product Information

• Dimethyl sulfoxide
• 1,1-Dimethoxyethane
• Diphenyldimethoxysilane
• Dimethyldimethoxysilane
• Dacthal
• (-)-Dimethyl D-tartrate
• Dimethyl malonate
• Dimethyl ether
• Dimethyl acetylenedicarboxylate
• Dimethyl fumarate
• 3-SULFOLENE
• Dimethyl sebacate
• N,N-Dimethylformamide
• Dimethyl malate
• DIMETHYL PHOSPHATE
• Dimethyl suberate
• Dimethyl sulfate
• Dimethyl carbonate