4-FLUOROPHENYLMAGNESIUM BROMIDE Chemical Properties

Melting point:

5 °C

Boiling point:

66°C

Density 

1.043 g/mL at 25 °C

Flash point:

−40 °F

storage temp. 

Flammables + water-Freezer (-20°C)e area

form 

Solution

color 

Clear yellow to red-brown

Water Solubility 

It reacts violently with water.

Sensitive 

Air & Moisture Sensitive

BRN 

636802

InChIKey

QYBFFRXNNFXREA-UHFFFAOYSA-M

CAS DataBase Reference

352-13-6

EPA Substance Registry System

Magnesium, bromo(4-fluorophenyl)- (352-13-6)

Safety Information

Hazard Codes 

F+,C,F

Risk Statements 

12-14-22-34-66-67-11-40-37-19

Safety Statements 

16-26-36/37/39-43-45-7/8-33-8-7

RIDADR 

UN 2924 3/PG 2

WGK Germany 

1

F 

10-21

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29319090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

4-FLUOROPHENYLMAGNESIUM BROMIDE Usage And Synthesis

Chemical Properties

clear yellow to red-brown solution

Uses

4-Fluorophenylmagnesium bromide is used as a reagent for the introduction of the 4-Fluorophenyl group.

Uses

4-Fluorophenylmagnesium bromide solution (Grignard reagent) can be used as a reagent in the synthesis of:

• Useful key intermediate in the synthesis of paroxetine.
• Arylsulfides via cross-coupling reaction with thiols.
• 4-Arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as androgen receptor antagonists.
• Grignard intermediate for preparing aprepitant.

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