Julolidine Chemical Properties

Melting point:

34-36 °C(lit.)

Boiling point:

170-173°C 31mm

Density 

1.0030

refractive index 

1.5680

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

pka

6.54±0.20(Predicted)

form 

Liquid After Melting

color 

Clear yellow to orange-brown

Water Solubility 

Soluble in toluene. Insoluble in water.

Sensitive 

Air Sensitive

BRN 

139925

InChIKey

DZFWNZJKBJOGFQ-UHFFFAOYSA-N

CAS DataBase Reference

479-59-4(CAS DataBase Reference)

NIST Chemistry Reference

Julolidine(479-59-4)

EPA Substance Registry System

1H,5H-Benzo[ij]quinolizine, 2,3,6,7-tetrahydro- (479-59-4)

Safety Information

Risk Statements 

52/53

Safety Statements 

24/25-61

WGK Germany 

3

TSCA 

Yes

HS Code 

29339900

MSDS

• Language:English Provider:Julolidine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Julolidine Usage And Synthesis

Chemical Properties

CLEAR YELLOW TO ORANGE-BROWN LIQUID AFTER MELTING

Uses

Julolidine used as amine building block and in chemoluminescent dye. Also used in photoconductive materials, chemiluminescence substances, chromogenic substrates in analytical redox reactions, dye intermediates, potential antidepressants and tranquilizers, nonlinear optical materials, high sensitivity photopolymerizable materials, and for improving color stability in photography.

Purification Methods

Purify julolidine by dissolving it in dilute HCl, steam is bubbled through the solution and the residual acidic solution is basified with 10N NaOH, extracted with Et2O, washed with H2O, dried (NaOH pellets), filtered, evaporated and distilled in vacuo. The distillate crystallises on cooling (m 39-40o). It develops a red colour on standing in contact with air for several days. The colour can be removed by distilling or dissolving in 2-3 parts of hexane, adding charcoal, filtering and cooling in an Me2CO/Dry-ice bath when julolidine crystallises out (85-90% yield m 39-40o). The hydrobromide [83646-41-7] has m 218o (239-242o), the picrate has m 174o(165o) and the methiodide crystallises from MeOH, with m 186o [Glass & Weisberger Org Synth Coll Vol III 504 1955, Smith & Yu J Org Chem 17 1285 1952, Beilstein 20 H 332, 20 I 133, 20 II 214, 20 III/IV 3281.] Highly TOXIC.

Julolidine(479-59-4)Related Product Information

• MEQUITAZINE
• Hydrochlorothiazide
• Benzo[b]thien-2-ylboronic acid
• Coumarin 337
• 8-HYDROXYJULOLIDINE
• SULFORHODAMINE 101
• 9-Formyl-8-hydroxy-1,1,7,7-tetramethyljulolidine
• Coumarin 314T
• Coumarin 314
• Coumarin 106
• Coumarin 338
• Coumarin 334
• Coumarin 343
• Coumarin 102
• 2,3,6,7-Tetrahydro-1H,5H-benzo[ij]quinolizine-9-carboxaldehyde
• Coumarin 153
• SULFORHODAMINE 101 ACID CHLORIDE
• RHODAMINE 101 INNER SALT