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Procysteine

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Procysteine Basic information

Product Name:
Procysteine
Synonyms:
  • (4R)-2-Oxothiazolidine-4-carboxylic acid
  • (4R)-2-Oxothiazolidine-4α-carboxylic acid
  • L-2-Thiazolidinone-4-carboxylic Acid,L-2-Oxothiazolidine-4-carboxylic Acid
  • (4R)-2-ketothiazolidine-4-carboxylic acid
  • L-Thiazolidin-2-one-4-carboxylic acid, OTC, Procysteine, OTZ
  • Oxothiazolidine carboxylate
  • 4-Thiazolidinecarboxylicacid, 2-oxo-, (4R)-
  • L-2-Thiazolidinone-4-carboxylic Acid
CAS:
19771-63-2
MF:
C4H5NO3S
MW:
147.15
EINECS:
200-154-8
Product Categories:
  • CARBOXYLICACID
  • whitening and anti-aging material and other functions in cosmetics
Mol File:
19771-63-2.mol
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Procysteine Chemical Properties

Melting point:
174 °C (dec.)(lit.)
alpha 
-60 º (c=1 in H2O)
Density 
1.582±0.06 g/cm3(Predicted)
refractive index 
-64 ° (C=1, H2O)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Powder
pka
pKa (22°): 3.32
color 
White to Off-white
Water Solubility 
Soluble in water
Merck 
13,7019
BRN 
4179169
InChI
InChI=1S/C4H5NO3S/c6-3(7)2-1-9-4(8)5-2/h2H,1H2,(H,5,8)(H,6,7)/t2-/m0/s1
InChIKey
BMLMGCPTLHPWPY-REOHCLBHSA-N
SMILES
S1C[C@@H](C(O)=O)NC1=O
CAS DataBase Reference
19771-63-2(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
XJ5426650
HS Code 
2934.20.8000

MSDS

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Procysteine Usage And Synthesis

Chemical Properties

White crystalline powder

Uses

(R)-(-)-2-Oxothiazolidine-4-carboxylic Acid or Procysteine is a precursor to glutathione (GSH) which is an important antioxidant in plants, animals and fungi.

Definition

ChEBI: (4R)-2-oxo-4-thiazolidinecarboxylic acid is an organonitrogen compound and an organooxygen compound. It is functionally related to an alpha-amino acid.

Biological Activity

2-Oxothiazolidine-4-carboxylic acid augments glutathione and cysteine production.

in vivo

Oxothiazolidinecarboxylic acid treatment attenuates plantaris atrophy, restored glutathione levels, and increased catalase, Cu/Zn-SOD1, and Mn-SOD2 mRNA expression, but did not reduce other markers of oxidant stress or levels of these catabolic factors[1].

Animal Model:Male Sprague-Dawley rats (200-250 g, n= 6-7 rats/group)[1].
Dosage:0.35% (w/v).
Administration:Added to their diets at a concentration of 0.35% (w/v) for the final 12 wk.
Result:Increased fiber CSAs compared to the non-supplemented, alcohol-fed group.

ProcysteineSupplier

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