SALICYLIDENE SALICYLHYDRAZIDE Chemical Properties

Melting point:

280-284°C

storage temp. 

Store at RT

solubility 

DMSO: ~20 mg/mL

form 

solid

color 

off-white

BRN 

2944701

CAS DataBase Reference

3232-36-8(CAS DataBase Reference)

EPA Substance Registry System

Benzoic acid, 2-hydroxy-, [(2-hydroxyphenyl)methylene]hydrazide (3232-36-8)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36-37

WGK Germany 

3

TSCA 

Yes

HS Code 

29280000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

SALICYLIDENE SALICYLHYDRAZIDE Usage And Synthesis

Uses

SCS is a selective inhibitor of β1-containing GABAA receptors.

Definition

ChEBI: 2-hydroxy-N'-[(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]benzohydrazide is a member of salicylamides.

Biological Activity

Potent and selective partial inhibitor of β 1-containing GABA A receptors (IC 50 values are 4.5, 5.3 and 7.9 nM at α 2 β 1 γ 1 θ , α 2 β 1 γ 1 and α 2 β 1 γ 2s GABA A receptors respectively). May bind allosterically to a novel site on GABA A receptor.

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