SALICYLIDENE SALICYLHYDRAZIDE
SALICYLIDENE SALICYLHYDRAZIDE Basic information
- Product Name:
- SALICYLIDENE SALICYLHYDRAZIDE
- Synonyms:
-
- 2-HYDROXYBENZYLIDENE SALICYLHYDRAZIDE
- 2-HYDROXYBENZYLIDENE 2-HYDROXYBENZHYDRAZIDE
- 2-hydroxy-benzoicaci[(2-hydroxyphenyl)methylene]hydrazide
- (2-hydroxybenzylidene)salicylohydrazide
- Salicylidenesalicylhydrazide,97%
- 2-Hydroxybenzylidene 2-hydroxybenzhydrazide, NSC 87864, SCS
- SALICYLIDENE SALICYLHYDRAZIDE
- SALICYLIDENE SALICYLHYDRAZONE
- CAS:
- 3232-36-8
- MF:
- C14H12N2O3
- MW:
- 256.26
- EINECS:
- 221-773-2
- Product Categories:
-
- GABA/Glycine receptor
- Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
- Mol File:
- 3232-36-8.mol
SALICYLIDENE SALICYLHYDRAZIDE Chemical Properties
- Melting point:
- 280-284°C
- storage temp.
- Store at RT
- solubility
- DMSO: ~20 mg/mL
- form
- solid
- color
- off-white
- BRN
- 2944701
- CAS DataBase Reference
- 3232-36-8(CAS DataBase Reference)
- EPA Substance Registry System
- Benzoic acid, 2-hydroxy-, [(2-hydroxyphenyl)methylene]hydrazide (3232-36-8)
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36-37
- WGK Germany
- 3
- TSCA
- Yes
- HS Code
- 29280000
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
SALICYLIDENE SALICYLHYDRAZIDE Usage And Synthesis
Uses
SCS is a selective inhibitor of β1-containing GABAA receptors.
Definition
ChEBI: 2-hydroxy-N'-[(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]benzohydrazide is a member of salicylamides.
Biological Activity
Potent and selective partial inhibitor of β 1-containing GABA A receptors (IC 50 values are 4.5, 5.3 and 7.9 nM at α 2 β 1 γ 1 θ , α 2 β 1 γ 1 and α 2 β 1 γ 2s GABA A receptors respectively). May bind allosterically to a novel site on GABA A receptor.
in vivo
SCS (Salicylidene salicylhydrazide; 500-1000 mg/kg, i.p. or 800-1000 mg/kg, oral) produces abdominal constrictions in mice[2].
SCS (10-75 mg/kg; i.p.; once) shows antinociceptive activity against tonic, phasic and Capsaicin (HY-10448) nociception in mice[2].
SCS (10-75 mg/kg; i.p.; once) shows anti-inflammatory activity in mice[2].
SCS (50 and 75 mg/kg; i.p.; once) shows antinociceptive activity against neuropathic nociception[2].
| Animal Model: | BALB/c mice; tonic, phasic and Capsaicin (HY-10448) nociception model[2] |
| Dosage: | 10, 25, 50, and 75 mg/kg |
| Administration: | IP, single dose |
| Result: | Produced a significant protection on tonic, phasic and capsaicin nociception in a dose-dependent manner. |
| Animal Model: | BALB/c mice, Oxaliplatin (HY-17371)-induced neuropathic nociception model[2] |
| Dosage: | 50 and 75 mg/kg |
| Administration: | IP, single dose |
| Result: | Significantly attenuated the paw withdrawal threshold changes associated with Oxaliplatin. Significantly increased the percent antinociception during 30-120 min. |
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