2,6-Dichlorobenzyl alcohol Chemical Properties

Melting point:

96-98 °C(lit.)

Boiling point:

150°C 25mm

Density 

1.2970 (rough estimate)

refractive index 

1.5570 (estimate)

Flash point:

150°C/25mm

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

13.57±0.10(Predicted)

color 

White to Off-White

BRN 

1938356

InChIKey

WKKHCCZLKYKUDN-UHFFFAOYSA-N

CAS DataBase Reference

15258-73-8(CAS DataBase Reference)

NIST Chemistry Reference

2,6-Dichlorobenzyl alcohol(15258-73-8)

Safety Information

Hazard Codes 

Xi

Safety Statements 

24/25

WGK Germany 

3

RTECS 

DO0900000

Hazard Note 

Irritant

HS Code 

29062990

MSDS

• Language:English Provider:2,6-Dichlorobenzyl alcohol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,6-Dichlorobenzyl alcohol Usage And Synthesis

Chemical Properties

WHITE CRYSTALLINE POWDER

Uses

2,6-Dichlorobenzyl Alcohol is a useful reagent in organic synthesis.

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 707, 1988 DOI: 10.1016/S0040-4039(00)80190-2

Synthesis

General procedure for the synthesis of 2,6-dichlorobenzyl alcohol from 2,6-dichlorobenzaldehyde: To a solution of 2,6-dichlorobenzaldehyde (340 mg, 1.94 mmol) in anhydrous ethanol (4 mL) was added sodium borohydride (74 mg, 1.94 mmol) in batches. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, a 1 N hydrochloric acid solution (~5 mL) was slowly added to quench the reaction. Subsequently, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (10 mL) and washed sequentially with 1 N hydrochloric acid solution (10 mL) and deionized water (10 mL x 2). The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to give the target product 2,6-dichlorobenzyl alcohol (320 mg, 94% yield).

References

[1] ChemMedChem, 2016, vol. 11, # 23, p. 2607 - 2620
[2] Patent: CN103304571, 2018, B. Location in patent: Paragraph 0142; 0143; 0144
[3] RSC Advances, 2015, vol. 5, # 64, p. 52000 - 52006
[4] Catalysis Communications, 2017, vol. 94, p. 23 - 28
[5] Patent: CN109020779, 2018, A. Location in patent: Paragraph 0049; 0050

2,6-Dichlorobenzyl alcohol(15258-73-8)Related Product Information

• 1,2-Dichloroethane
• 1,3-Bis(chloromethyl)benzene
• Ethyl acetate
• Dichloroacetic acid
• 4,4'-Bis(chloromethyl)-1,1'-biphenyl
• 4-Hydroxybenzyl alcohol
• Benzyl alcohol
• 4-Nitrobenzyl alcohol
• Dichloroethane
• 4,6-Dichloropyrimidine
• Chlorthal
• 2,4,6-Trichlorobenzoic acid
• 1-(2,6-DICHLOROPHENYL)ETHANOL
• BENZAL CHLORIDE
• BOC-TYR(2,6-DI-CL-BZL)-OH
• 2,6-DICHLOROBENZYL METHYL ETHER
• Dacthal
• 2,4-DICHLOROBENZYL ALCOHOL