Basic information Safety Supplier Related

17ALPHA-HYDROXYPREGNENOLONE

Basic information Safety Supplier Related

17ALPHA-HYDROXYPREGNENOLONE Basic information

Product Name:
17ALPHA-HYDROXYPREGNENOLONE
Synonyms:
  • 17alpha-Hydroxy
  • (3b)-3,17-dihydroxy-Pregn-5-en-20-one
  • 17a-Hydroxypregnolone
  • 17ALPHA-LPHA-HYDROXYPREGNENOLONE
  • 5-Pregnen-3b,17-dihydroxy-3-one
  • 3β,17α-Dihydroxy-5-pregnen-20-one, 5-Pregnene-3β,17α-diol-20-one
  • 17-OH PREG
  • 17-OH Pregnenolone
CAS:
387-79-1
MF:
C21H32O3
MW:
332.48
EINECS:
206-862-6
Product Categories:
  • Steroids
Mol File:
387-79-1.mol
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17ALPHA-HYDROXYPREGNENOLONE Chemical Properties

Melting point:
273℃
Flash point:
9℃
storage temp. 
-20°C
solubility 
Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated)
form 
Solid
Boiling point:
478.4±45.0 °C(Predicted)
Density 
1.15±0.1 g/cm3(Predicted)
pka
13.02±0.70(Predicted)
color 
White to Off-White
CAS DataBase Reference
387-79-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
7-16-36/37-45
RIDADR 
UN1230 - class 3 - PG 2 - Methanol
WGK Germany 
3
RTECS 
TU5548000

MSDS

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17ALPHA-HYDROXYPREGNENOLONE Usage And Synthesis

Description

17α-hydroxy Pregnenolone is a metabolite of pregnenolone and a precursor in the biosynthesis of dehydroepiandrosterone (DHEA; ). It is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and then converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Plasma levels of 17α-hydroxy pregnenolone are elevated in patients with type II 3β-hydroxysteroid dehydrogenase deficiency, a form of congenital adrenal hyperplasia.

Uses

17α-hydroxypregnenolone has been used as a substrate for the enzyme 3β‐hydroxysteroid dehydrogenase (3β‐HSD) expressed in COS1 cells.

General Description

17α-hydroxypregnenolone is a derived from pregnenolone.

Biochem/physiol Actions

17α-hydroxypregnenolone acts as a precursor for cortisol and sex steroids.

17ALPHA-HYDROXYPREGNENOLONESupplier

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