17ALPHA-HYDROXYPREGNENOLONE CAS#: 387-79-1

17ALPHA-HYDROXYPREGNENOLONE Basic information

Product Name:

17ALPHA-HYDROXYPREGNENOLONE

Synonyms:

17alpha-Hydroxy
(3b)-3,17-dihydroxy-Pregn-5-en-20-one
17a-Hydroxypregnolone
17ALPHA-LPHA-HYDROXYPREGNENOLONE
5-Pregnen-3b,17-dihydroxy-3-one
3β,17α-Dihydroxy-5-pregnen-20-one, 5-Pregnene-3β,17α-diol-20-one
17-OH PREG
17-OH Pregnenolone

CAS:

387-79-1

MF:

C21H32O3

MW:

332.48

EINECS:

206-862-6

Product Categories:

Steroids

Mol File:

387-79-1.mol

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17ALPHA-HYDROXYPREGNENOLONE Chemical Properties

Melting point:: 273℃
Flash point:: 9℃
storage temp.: -20°C
solubility: Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated)
form: Solid
Boiling point:: 478.4±45.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
pka: 13.02±0.70(Predicted)
color: White to Off-White
CAS DataBase Reference: 387-79-1(CAS DataBase Reference)

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Safety Information

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45
RIDADR: UN1230 - class 3 - PG 2 - Methanol
WGK Germany: 3
RTECS: TU5548000

MSDS

Language:English Provider:SigmaAldrich

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17ALPHA-HYDROXYPREGNENOLONE Usage And Synthesis

Description

17α-hydroxy Pregnenolone is a metabolite of pregnenolone and a precursor in the biosynthesis of dehydroepiandrosterone (DHEA; ). It is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and then converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Plasma levels of 17α-hydroxy pregnenolone are elevated in patients with type II 3β-hydroxysteroid dehydrogenase deficiency, a form of congenital adrenal hyperplasia.

Uses

17α-hydroxypregnenolone has been used as a substrate for the enzyme 3β‐hydroxysteroid dehydrogenase (3β‐HSD) expressed in COS1 cells.

General Description

17α-hydroxypregnenolone is a derived from pregnenolone.

Biochem/physiol Actions

17α-hydroxypregnenolone acts as a precursor for cortisol and sex steroids.

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