17ALPHA-HYDROXYPREGNENOLONE
17ALPHA-HYDROXYPREGNENOLONE Basic information
- Product Name:
- 17ALPHA-HYDROXYPREGNENOLONE
- Synonyms:
-
- 17alpha-Hydroxy
- (3b)-3,17-dihydroxy-Pregn-5-en-20-one
- 17a-Hydroxypregnolone
- 17ALPHA-LPHA-HYDROXYPREGNENOLONE
- 5-Pregnen-3b,17-dihydroxy-3-one
- 3β,17α-Dihydroxy-5-pregnen-20-one, 5-Pregnene-3β,17α-diol-20-one
- 17-OH PREG
- 17-OH Pregnenolone
- CAS:
- 387-79-1
- MF:
- C21H32O3
- MW:
- 332.48
- EINECS:
- 206-862-6
- Product Categories:
-
- Steroids
- Mol File:
- 387-79-1.mol
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17ALPHA-HYDROXYPREGNENOLONE Chemical Properties
- Melting point:
- 273℃
- Flash point:
- 9℃
- storage temp.
- -20°C
- solubility
- Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated)
- form
- Solid
- Boiling point:
- 478.4±45.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- pka
- 13.02±0.70(Predicted)
- color
- White to Off-White
- CAS DataBase Reference
- 387-79-1(CAS DataBase Reference)
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Safety Information
- Hazard Codes
- F,T
- Risk Statements
- 11-23/24/25-39/23/24/25
- Safety Statements
- 7-16-36/37-45
- RIDADR
- UN1230 - class 3 - PG 2 - Methanol
- WGK Germany
- 3
- RTECS
- TU5548000
MSDS
- Language:English Provider:SigmaAldrich
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17ALPHA-HYDROXYPREGNENOLONE Usage And Synthesis
Description
17α-hydroxy Pregnenolone is a metabolite of pregnenolone and a precursor in the biosynthesis of dehydroepiandrosterone (DHEA; ). It is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and then converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Plasma levels of 17α-hydroxy pregnenolone are elevated in patients with type II 3β-hydroxysteroid dehydrogenase deficiency, a form of congenital adrenal hyperplasia.
Uses
17α-hydroxypregnenolone has been used as a substrate for the enzyme 3β‐hydroxysteroid dehydrogenase (3β‐HSD) expressed in COS1 cells.
General Description
17α-hydroxypregnenolone is a derived from pregnenolone.
Biochem/physiol Actions
17α-hydroxypregnenolone acts as a precursor for cortisol and sex steroids.
17ALPHA-HYDROXYPREGNENOLONESupplier
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17ALPHA-HYDROXYPREGNENOLONE(387-79-1)Related Product Information
- 21-hydroxypregnenolone 3-acetate
- 17ALPHA-HYDROXYPREGNENOLONE-3,17-DIACETATE,17-HYDROXYPREGNENOLONE DIACETATE,17A-HYDROXYPREGNENOLONE-3,17-DIACETATE,17ALPHA-HYDROXYPREGNENOLONE-3,17-DIACETATE
- Pregnenolone
- 16BETA-METHYL-17ALPHA-HYDROXYPREGNENOLONE,16BETA-METHYL-17ALPHA-HYDROXYPREGNENOLONE
- 17ALPHA-HYDROXYPREGNENOLONE 17-ACETATE,17ALPHA-HYDROXYPREGNENOLONE 17-ACETATE,17A-HYDROXYPREGNENOLONE-17-ACETATE
- 17-HYDROXYPREGNENOLONE 3-ACETATE,17ALPHA-HYDROXYPREGNENOLONE 3-ACETATE,17A-hydroxypregnenolone 3-acetate,17ALPHA-HYDROXYPREGNENOLONE 3-ACETATE
- 20-BETA-HYDROXYPREGNENOLONE
- 6-methyl-17alpha-hydroxypregnenolone diacetate,6-methyl-17alpha-hydroxypregnenolone diacetate
- 16-METHYLENE-17ALPHA-HYDROXYPREGNENOLONE 3-ACETATE
- 16-ALPHA-HYDROXYPREGNENOLONE,16-ALPHA-HYDROXYPREGNENOLONE-3-SULFATE,16A-hydroxypregnenolone
- 11-BETA-HYDROXYPREGNENOLONE
- 21-HYDROXYPREGNENOLONE 3,21-DIACETATE
- 17ALPHA-HYDROXYPREGNENOLONE-21,21,21-D3
- 21-HYDROXYPREGNENOLONE
- HYDROXYPREGNENOLONE, 17a-(RG)
- 17-HYDROXYPREGNENOLONE-7-CM:BSA
- 17-HYDROXYPREGNENOLONE CARBOXYMETHYLOXIME,17-HYDROXYPREGNENOLONE CARBOXYMETHYLOXIME:BSA
- 21-HYDROXYPREGNENOLONE 21-SODIUM SULPHATE