Boc-D-Val-OMe Chemical Properties

Boiling point:

306.0±25.0 °C(Predicted)

Density 

1.020±0.06 g/cm3(Predicted)

storage temp. 

Store at Room Tem.

pka

11.13±0.46(Predicted)

Boc-D-Val-OMe Usage And Synthesis

Uses

D-Boc Valine methyl ester is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].

References

[1] Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45. PMID:12702571

Boc-D-Val-OMe(106391-85-9)Related Product Information

• Boc-D-Valine
• D-VALINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-METHYL-, METHYL ESTER
• BOC-D-VAL-O-CH2-PHI-CH2-COOH
• Boc-D-Val-OMe
• (1R,2S)-1-BOC-AMINO-2-VINYLCYCLOPROPANECARBOXYLIC ACID ETHYL ESTER