Bis(4-fluorophenyl)-methanone Chemical Properties

Melting point:

102-105 °C (lit.)

Boiling point:

137°C (3 torr)

Density 

1.2543 (estimate)

vapor pressure 

0.005Pa at 20℃

Flash point:

170-172°C/10mm

storage temp. 

Sealed in dry,Room Temperature

solubility 

Insoluble in water

form 

Crystalline Powder

color 

White to slightly yellow

Water Solubility 

8.757mg/L at 20℃

BRN 

516231

InChI

1S/C13H8F2O/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8H

InChIKey

LSQARZALBDFYQZ-UHFFFAOYSA-N

SMILES

Fc1ccc(cc1)C(=O)c2ccc(F)cc2

LogP

3.37 at 20℃

CAS DataBase Reference

345-92-6(CAS DataBase Reference)

NIST Chemistry Reference

4,4'-Difluorobenzophenone(345-92-6)

EPA Substance Registry System

4,4'-Difluorobenzophenone (345-92-6)

Safety Information

Hazard Codes 

Xi,N,Xn

Risk Statements 

36/37/38-51/53-22

Safety Statements 

26-37/39-36-61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

RTECS 

DJ0685000

TSCA 

TSCA listed

HazardClass 

IRRITANT

HS Code 

29143990

Storage Class

13 - Non Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Chronic 2
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:Bis(4-fluorophenyl)-methanone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Bis(4-fluorophenyl)-methanone Usage And Synthesis

Chemical Properties

white to slightly yellow crystalline powder

Uses

4,4′-Difluorobenzophenone has been used in the study of thermal stability, water uptake and proton conductivity of carboxylated, carboxylated/sulfonated, and crosslinked membranes.

Synthesis Reference(s)

Journal of the American Chemical Society, 90, p. 540, 1968 DOI: 10.1021/ja01004a087

General Description

4,4′-Difluorobenzophenone is typically used as a starting material for the preparation of polyetheretherketone (PEEK) polymer, a high-temperature thermoplastic, which finds wide use in dentistry as well as in automotive, oil industries, etc.

Synthesis

??Mix 200g of fluorobenzene with 65g of anhydrous aluminum trichloride, cool to 0-5??, add 100g of p-fluorotrichloromethylbenzene dropwise reaction for 20min, get 4,4'-difluorophenyl dichloromethane;

??Add 4,4'-difluorophenyl dichloromethane to 600g of water mixing, heating To the azeotropic temperature at the same time recycling fluorobenzene 140g, reaction 5h, cooling to room temperature, filtration, drying to get light yellow solid crude 102g, using 200g methanol recrystallization, filtration, washing, drying, to get the melting point of 107-108 ?? white crystals 92g, the purity of gas chromatography analysis of 99.9%, the yield is 90%. Detected by 1H-NMR: ??7.28 (4H, t, hydrogen adjacent to the fluorine on the benzene ring); ??7.81 (4H, m, hydrogen adjacent to the carbonyl on the benzene ring), which is consistent with the structure of 4,4'-difluorobenzophenone.

Bis(4-fluorophenyl)-methanone(345-92-6)Related Product Information

• 3,4-DIMETHYLBENZENE-1-CARBONYL CHLORIDE
• Doxofylline Impurity 11
• Vernakalant Impurity 1 ((3S,1'S,2'S)-Isomer) HCl
• Vernakalant-d6 HCl
• 4-ethenyl-1,2-dimethyl-benzene
• Vortioxetine Impurity 32
• 1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-7,8-dinitro-
• 16-Hydroxy Capsaicin
• 3-METHOXYBENZALACETONE
• Diphenylmethane
• 2,4'-Difluorobenzophenone
• 3,4-Difluorobenzophenone
• 2,4-Difluorobenzophenone
• 3,3'-Difluorobenzophenone
• 2,6-DIFLUOROBENZOPHENONE
• 4-FLUORODIPHENYLMETHANE
• Benzophenone
• 4,4'-Difluorodiphenylmethane