1-Bromo-2,4-difluorobenzene Chemical Properties

Melting point:

-4 °C (lit.)

Boiling point:

145-146 °C (lit.)

Density 

1.708 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.505(lit.)

Flash point:

125 °F

storage temp. 

Sealed in dry,2-8°C

form 

Liquid

color 

Clear colorless to brown

Specific Gravity

1.708

PH

5.02 at 24℃ and 10g/L

Water Solubility 

INSOLUBLE

BRN 

1680892

InChIKey

MGHBDQZXPCTTIH-UHFFFAOYSA-N

CAS DataBase Reference

348-57-2(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1-bromo-2,4-difluoro-(348-57-2)

Safety Information

Hazard Codes 

Xi,F

Risk Statements 

10-36/37/38

Safety Statements 

16-26-36/37/39-37/39-36

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

Hazard Note 

Flammable

HazardClass 

3

PackingGroup 

III

HS Code 

29036990

MSDS

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1-Bromo-2,4-difluorobenzene Usage And Synthesis

Chemical Properties

Clear colorless to brown liqui

Uses

1-Bromo-2,4-difluorobenzene has been used in:

• preparation of (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-sila-ethoxy)-propan-1-one
• enantiomeric preparation of the key intermediate of chiral azole antifungal agents by a chemoenzymatic process

General Description

1-Bromo-2,4-difluorobenzene undergoes lithiation exclusively at the position having two adjacent halogen substituents, to yield 6-bromo-2,3-difluorobenzoic acid.

1-Bromo-2,4-difluorobenzene(348-57-2)Related Product Information

• Decabromodiphenyl Ethane
• 1,3-Difluorobenzene
• 4-Bromofluorobenzene
• 2,4-Difluorophenol
• Transfluthrin
• Florfenicol
• 1,2-Difluorobenzene
• 4-Fluorobenzaldehyde
• 2,4,5-TRIFLUORO-6-BROMOANILINE
• 5-BROMO-1,2-DIFLUORO-3-TRIFLUOROMETHYL-BENZENE
• 5-Bromo-1,2,3-trifluorobenzene
• 1,2-Dibromotetrafluorobenzene
• 1,2-Dibromo-4,5-difluorobenzene
• 1-BROMO-2,3,4,5-TETRAFLUOROBENZENE
• 2-BROMO-4,5,6-TRIFLUOROANILINE
• 1-bromo-2,3,4,6-tetrafluorobenzene
• Bromine
• 1,2-DIBROMO-3,4,5-TRIFLUOROBENZENE