PROPARACAINE Chemical Properties

pka

pKa 3.22(H2O) (Uncertain)

Safety Information

Hazardous Substances Data

298-50-0(Hazardous Substances Data)

PROPARACAINE Usage And Synthesis

Uses

Anticholinergic.

Uses

Propantheline is used for treating stomach ulcers.

Definition

ChEBI: Propantheline is a member of xanthenes.

brand name

Pro-Banthine (Searle).

Pharmacology

The pharmacological action of propantheline is qualitatively similar to atropine. It has a weaker effect on the CNS than atropine. Unlike atropine, it exhibits greater ganglioblocking action than antimuscarinic action. Moreover, upon overdose it causes neuromuscular curare-like blockage.

Synthesis

Propanetheline, N-methyl-N-(1-methylethyl)-N-[2-[(9H-xanthen-9- ylcarbonyl) oxy]ethyl]-2-propanaminium bromide (14.1.11), is synthesized by reacting xanthen-9-carboxylic acid chloride with 2-di-iso-propylaminoethanol, giving the ester (14.1.10), which upon reaction with methylbromide turns into the quaternary salt, propantheline (14.1.11) [12,13].

Veterinary Drugs and Treatments

Proparacaine is a rapid acting topical anesthetic useful for a variety of ophthalmic procedures including tonometry (intraocular pressure measurement), relief of corneal pain to facilitate examination, biopsy/sample collection, and to distinguish between corneal and uveal pain. Proparacaine primarily anesthetizes the cornea; with limited penetration into conjunctiva. Anesthesia is of short duration (5 – 10 minutes).

PROPARACAINE(298-50-0)Related Product Information

• Pranoprofen
• Bendazac L-lysine
• Hyaluronidase
• Dyclonine hydrochloride
• Tetracaine hydrochloride
• Pirenoxine
• PROPARACAINE HYDROCHLORIDE,PROPARACAINE HCL,PROXYMETACAINEHYDROCHLORIDE/PROPARACAINE
• 2-diethylaminoethyl 4-ethoxybenzoate
• proxymetacaine
• Methyl 3-amino-4-methoxybenzoate
• Methyl 3-amino-4-hydroxybenzoate
• ETHYL 3-AMINO-4-METHOXYBENZOATE
• PROPARACAINE
• 3-Amino-4-methoxybenzoic acid