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Polyinosinic acid-polycytidylic acid

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Polyinosinic acid-polycytidylic acid Basic information

Product Name:
Polyinosinic acid-polycytidylic acid
Synonyms:
  • POLY(I) POLY(C)
  • POLYINOSINIC ACID POLYCYTIDYLIC ACID
  • POLYINOSINIC POLYCYTIDYLIC ACID
  • polyinosinic:polycytidylic acid copolymer
  • POLYCYTIDYLIC-INOSINIC ACID
  • Polyinosinic-polytidylin Acid.
  • POLYINOSINIC ACID . POLYCYTIDYLIC ACID, LYOPHILIZED
  • POLYCYTIDYLIC-INOSINIC ACID POTASSIUM
CAS:
24939-03-5
MF:
C19H27N7O16P2
MW:
671.41
EINECS:
1308068-626-2
Product Categories:
  • Material
Mol File:
24939-03-5.mol
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Polyinosinic acid-polycytidylic acid Chemical Properties

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Water (Slightly)
form 
Solid
color 
White to Off-White
Water Solubility 
Soluble to 3 mg/ml in water
Stability:
Hygroscopic
InChIKey
ACEVNMQDUCOKHT-WOQDZEJINA-N
SMILES
O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,22,23,24,32,r|
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Safety Information

WGK Germany 
3
RTECS 
TR0175000

MSDS

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Polyinosinic acid-polycytidylic acid Usage And Synthesis

Uses

Poly(I:C) is a toll-like receptor 3 dsRNA inflammatory stimulant.

Definition

ChEBI: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.

Biological Activity

poly (i:c), a synthetic double-stranded rna (dsrna) analog, is an immunostimulant that acts as the most potent interferon (ifn) inducer. toll-like receptor- 3 (tlr3) agonist[1].mixtures that included the tlr7/8 agonists r848 or cl075, combined with the poly (i:c), yield 3-d mature dendritic cells [2].commonly used to stimulate immune system activation in vivo. also promotes maturation of hpsc-derived cardiomyocytes[3].[1]. li y g, siripanyaphinyo u, tumkosit u, et al. poly (i:c), an agonist of toll-like receptor-3, inhibits replication of the chikungunya virus in beas-2b cells. virology journal, 2012, 9(1): 114.[2]. spranger s, javorovic m, burdek m, et al. generation of th1-polarizing dendritic cells using the tlr7/8 agonist cl075. the journal of immunology, 2010, 185(1): 738-747.[3]. biermann m1, cai w2, lang d, et al. epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation. stem cells, 2019, 37(7): 910-923.

in vivo

Polyinosinic-polycytidylic acid (2.5-10 mg/mL, Stereotaxic injection, single dose) induces a sustained inflammatory reaction in the substantia nigra (SN) and in the dorsolateral striatum. [2].
Polyinosinic-polycytidylic acid (10 μg/mouse, Intraperitoneal injection, single dose) decreases lung tumor growth in mice[3].
Polyinosinic-polycytidylic acid (1.25 mg/kg, Intraperitoneal injection, single dose) exerts therapeutic effects against cerebral I/R injury through the downregulation of TLR4/MyD88 signaling via TLR3 in MCAO model mice[5].

Animal Model:lung tumor-bearing mice[3]
Dosage:10 μg/mouse
Administration:Intraperitoneal injection (i.p.)
Result:Induced a significant decrease in the growth of pulmonary metastases in tumor-bearing mice. Reduced the amount of lung foci to ≈ 40%. Significantly increased BAL fluid cell numbers. Increased the level of INF-γ and IL-17A, decreased the levels of IL-13. Increased TLR3 expression.
Animal Model:Middle cerebral artery occlusion (MCAO) model mice[5]
Dosage:1.25 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Reduced focal cerebral I/R injury. Increased the expression of Bcl2, Hsp27, and Hsp70, decreased Bax expression, and reduced cellular degeneration and apoptosis. Protected against cerebral ischemia and conferred protection against cerebral I/R injury through the downregulation of TLR4 signaling via TLR3.

IC 50

Bcl-2; Bax; IL-17A; IL-13; HSP70

Polyinosinic acid-polycytidylic acid Preparation Products And Raw materials

Raw materials

Sodium nitriteEpichlorohydrin1-Oxa-4-azacyclohexaneAmmonium sulfateSULFATE STANDARDCellulose microcrystallineRibonucleic acidAgarTributylamineInosinic AcidCreatine5'—NUCLEOTIDECytidylic acidPOLYNUCLEOTIDE PHOSPHORYLASE FROM BACILYttrium oxide sulfate, terbium-doped TAQ DNA POLYMERASE 5U/UL

Polyinosinic acid-polycytidylic acidSupplier

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021-33686691 18001850931;
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