Basic information Description References Safety Supplier Related
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Psoralen

Basic information Description References Safety Supplier Related

Psoralen Basic information

Product Name:
Psoralen
Synonyms:
  • PSORALEN
  • Fructus Psoraleae extract
  • Psoralen, >=99%
  • TGRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRY MJJNNNNNNN
  • Psoralea corylifolia Linn. Extract
  • furo(2’,3’,7,6)coumarin
  • furo(2’,3’:7’,6)coumarin
  • Furo(4',5',6,7)coumarin
CAS:
66-97-7
MF:
C11H6O3
MW:
186.16
EINECS:
200-639-7
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Coumarins
  • Inhibitors
Mol File:
66-97-7.mol
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Psoralen Chemical Properties

Melting point:
160-162 °C
Boiling point:
280.64°C (rough estimate)
Density 
1.2477 (rough estimate)
refractive index 
1.6310 (estimate)
storage temp. 
2-8°C
form 
neat
Water Solubility 
65.16mg/L(25 ºC)
λmax
328nm(EtOH)(lit.)
Merck 
14,7928
BRN 
152784
InChIKey
ZCCUUQDIBDJBTK-UHFFFAOYSA-N
CAS DataBase Reference
66-97-7(CAS DataBase Reference)
NIST Chemistry Reference
7H-furo[3,2-g][1]benzopyran-7-one(66-97-7)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
RTECS 
LV0944000
8-10
HS Code 
29339900
Hazardous Substances Data
66-97-7(Hazardous Substances Data)

MSDS

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Psoralen Usage And Synthesis

Description

Psoralen is a kind of naturally occurring furocoumarin. It is naturally occurred in the seeds of Psoralea corylifolia as well as in the common fig, celery, parsley, West Indian Satinwood and all citrus fruits. It is capable of binding to DNA via single- and double-strand cross-linking upon photoactivation with UV radiation. It can intercalate with DNA, blocking its synthesis and cell division. For this reason, it is an important mutagen and can be used in related molecular biology studies. It also exhibits anti- proliferative, anti-allergenic and anti-histamine functions. It can also be used in PUVA treatment for skin diseases such as psoriasis, eczema and vitiligo. It is also effective tanning activator in sunscreens. Some of its derivatives, e.g. amino-psoralen, amotosalen HCl, can even inactivate pathogens in blood products.

References

https://en.wikipedia.org/wiki/Psoralen
https://pubchem.ncbi.nlm.nih.gov/compound/Psoralen#section=Top

Chemical Properties

Crystalline Solid

Uses

Use as photochemical probe in biological systems

Uses

Psoralens are phytoalexins; they are used by plants in a defensive response to attacks by fungi and insects. They have also shown photosensitizing and phototoxic effects in animals and humans and have been used in photochemotherapy for management of vitiligo, psoriasis, and mycosis fungoides. Used as photochemical probe in biological systems.

Uses

As photochemical probe in biological systems: P.-S. Song, C.-N. Ou, Ann. N.Y. Acad. Sci. 346, 355 (1980).

Definition

ChEBI: The simplest member of the class of psoralens that is 7H-furo[3,2-g]chromene having a keto group at position 7. It has been found in plants like Psoralea corylifolia and Ficus salicifolia.

Synthesis Reference(s)

Journal of the American Chemical Society, 106, p. 6735, 1984 DOI: 10.1021/ja00334a044
Synthetic Communications, 37, p. 63, 2007 DOI: 10.1080/00397910600978093

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