Ethyl acetimidate hydrochloride Chemical Properties

Melting point:

112-114 °C(lit.)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

water: soluble50mg/mL, clear, colorless

form 

Crystalline Powder

color 

White

Water Solubility 

Soluble in water (50mg/L).

Sensitive 

Moisture Sensitive

BRN 

3552401

Stability:

Hygroscopic, Moisture Sensitive

InChIKey

WGMHMVLZFAJNOT-UHFFFAOYSA-N

CAS DataBase Reference

2208-07-3(CAS DataBase Reference)

EPA Substance Registry System

Ethanimidic acid, ethyl ester, hydrochloride (2208-07-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

F 

3-10-21

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29252900

MSDS

• Language:English Provider:Ethyl acetimidate hydrochloride
• Language:English Provider:SigmaAldrich
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Ethyl acetimidate hydrochloride Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

Ethyl acetimidate hydrochloride was used in preparation of amidinated carbonic anhydrase via chemical modification of human erythrocyte carbonic anhydrase. It was also used in synthesis of methyl 2-methyl-2-thiazoline-4-carboxylate hydrochloride.

Purification Methods

Recrystallise the hydrochloride by dissolving it in the minimum volume of super dry EtOH and adding dry Et2O or from dry Et2O. Dry it in a vacuum and store it in a vacuum desiccator with P2O5. Alternatively it could be crystallised from EtOH (containing a couple of drops of ethanolic HCl) and adding dry Et2O. Filter and dry it in a vacuum desiccator over H2SO4 and NaOH. [Pinner Chem Ber 16 1654 1883, Glickman & Cope J Am Chem Soc 67 1020 1945, Chaplin & Hunter J Chem Soc 1118 1937, McElvain & Schroeder J Am Chem Soc 71 40 1949, McElvain & Tate J Am Chem Soc 73 2233 1951, Methods Enzymol 25 585 1972, Beilstein 2 III 418.]

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