Ethyl dichlorophosphate Chemical Properties

Melting point:

-42.5 °C

Boiling point:

60-65 °C10 mm Hg(lit.)

Density 

1.373 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.434(lit.)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

form 

Liquid

color 

Clear colorless to pale brown

CAS DataBase Reference

1498-51-7(CAS DataBase Reference)

NIST Chemistry Reference

Ethyl dichlorophosphate(1498-51-7)

EPA Substance Registry System

Ethyl dichlorophosphate (1498-51-7)

Safety Information

Hazard Codes 

T+,C,Xi

Risk Statements 

26-34-22

Safety Statements 

26-28-36/37/39-45

RIDADR 

UN 3390 6.1/PG 1

WGK Germany 

3

RTECS 

TD4390000

HazardClass 

8

PackingGroup 

III

HS Code 

29209090

Hazardous Substances Data

1498-51-7(Hazardous Substances Data)

MSDS

• Language:English Provider:Ethyl phosphorodichloridate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

Ethyl dichlorophosphate Usage And Synthesis

Chemical Properties

Light Yellow Liquid

Uses

Ethyl Dichlorophosphate is an intermediate used in the synthesis of b-D-2'-deoxy-2'-a-fluoro-2'-b-C-methyluridine nucleotide prodrug (PSI-7977) for treatment of hepatitis C virus. It is also used to prepare dialkylphosphocholines with antiprotozoal, antifungal and antitumor activities.

General Description

Ethyl dichlorophosphate is strongly irritating to skin. Ethyl dichlorophosphate may cause visible destruction or irreversible alterations in human skin tissue at the site of contact. Ethyl dichlorophosphate is very toxic by ingestion, inhalation, or by skin absorption. Ethyl dichlorophosphate may be combustible though Ethyl dichlorophosphate may require some effort to ignite.

Air & Water Reactions

Reacts with water to form hydrogen chloride(hydrochloric acid)

Reactivity Profile

Organophosphates, such as Ethyl dichlorophosphate, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Health Hazard

Inhalation of vapor irritates nose and throat. Contact with liquid causes severe burns of eyes and skin. Ingestion causes severe burns of mouth and stomach.

Safety Profile

A corrosive material that is very toxic to tissue. A severe eye, skin, and mucous membrane irritant. When heated to decomposition it emits very toxic fumes of Cland POx.

Ethyl dichlorophosphate(1498-51-7)Related Product Information

• Dichloroethane
• Triethyl phosphite
• ETHYL PHOSPHATE
• Diethyl phosphite
• Ethyl acetate
• Ethyl propionate
• Ethyl formate
• Trinexapac-ethyl
• Triethyl phosphate
• 2-Ethoxyethanol
• ISOXADIFEN-ETHYL
• Ethanol
• Ethylparaben
• Diethyl ether
• 2-CHLOROETHYLPHOSPHORIC ACID DICHLORIDE
• 2,2,2-TRIBROMOETHYL DICHLOROPHOSPHATE
• 2-PHTHALIMIDOETHYL PHOSPHORODICHLORIDATE
• 2,2,2-TRICHLOROETHYL DICHLOROPHOSPHATE