N-NITROSOMORPHOLINE Chemical Properties

Melting point:

29°C

Boiling point:

225℃

Density 

1.2829 (rough estimate)

refractive index 

1.4880 (estimate)

Flash point:

29 °C

storage temp. 

2-8°C

Water Solubility 

Completely soluble in water

solubility 

DMSO : 100 mg/mL (861.18 mM)

pka

-5.72±0.20(Predicted)

color 

White or Colorless to Yellow

Merck 

14,6640

Stability:

Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents. Refrigerate, store in the dark.

IARC

2B (Vol. 17, Sup 7) 1987

EPA Substance Registry System

N-Nitrosomorpholine (59-89-2)

Safety Information

Hazard Codes 

Xn,T,F

Risk Statements 

22-40-39/23/24/25-23/24/25-11

Safety Statements 

36/37-45-16-7

RIDADR 

UN 2810 6.1/PG 3

WGK Germany 

3

RTECS 

QE7525000

HS Code 

2934.99.9001

HazardClass 

6.1(b)

PackingGroup 

III

Hazardous Substances Data

59-89-2(Hazardous Substances Data)

Toxicity

LD50 orally in rats: 282 mg/kg (Druckrey)

MSDS

• Language:English Provider:SigmaAldrich

N-NITROSOMORPHOLINE Usage And Synthesis

Chemical Properties

yellow crystals or gold liquid

Uses

Solvent for polyacrylonitrile; present during rubber manufacturing

Uses

N-Nitrosomorpholine, a frequently used genotoxic model carcinogen. Toxicogenomic analysis of N-Nitrosomorpholine induced changes in rat liver.

Definition

ChEBI: A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco.

Synthesis Reference(s)

Synthetic Communications, 22, p. 2607, 1992 DOI: 10.1080/00397919208021659

General Description

Yellow crystals. Golden liquid with many crystals at 68°F.

Air & Water Reactions

Water soluble.

Reactivity Profile

N-NITROSOMORPHOLINE is incompatible with strong oxidizing agents .

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition N-NITROSOMORPHOLINE emits toxic fumes of nitrogen oxides.

Fire Hazard

Flash point data for N-NITROSOMORPHOLINE are not available; however, N-NITROSOMORPHOLINE is probably combustible.

Biochem/physiol Actions

Tumor initiator in rodent liver, trachea, nasal cavity, esophagus, kidney, lung, and thyroid.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by inhalation. Human mutation data reported. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.

Carcinogenicity

N-Nitrosomorpholine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

N-NITROSOMORPHOLINE(59-89-2)Related Product Information

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