4-Phenylpyridine Chemical Properties

Melting point:

69-73 °C (lit.)

Boiling point:

274-275 °C (lit.)

Density 

1.1088 (rough estimate)

refractive index 

1.6210 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform, Methanol

form 

Crystalline Powder

pka

5.45±0.10(Predicted)

color 

Light yellow to beige

Water Solubility 

SOLUBLE

BRN 

110490

LogP

2.590

CAS DataBase Reference

939-23-1(CAS DataBase Reference)

NIST Chemistry Reference

4-phenyl-pyridine(939-23-1)

EPA Substance Registry System

4-Phenylpyridine (939-23-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

UT7141000

F 

10

HazardClass 

IRRITANT, KEEP COLD

HS Code 

29333990

MSDS

• Language:English Provider:4-Phenylpyridine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

4-Phenylpyridine Usage And Synthesis

Chemical Properties

LIGHT YELLOW TO BEIGE CRYSTALLINE POWDER

Uses

4-Phenylpyridine is a useful synthetic intermediate. 4-Phenylpyridine has been shown to induce inhibition of mitochondrial respiration in mice.

Definition

ChEBI: 4-Phenylpyridine is a phenylpyridine.

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 1702, 1956 DOI: 10.1021/ja01589a060
Synthetic Communications, 21, p. 619, 1991 DOI: 10.1080/00397919108020828
Tetrahedron Letters, 36, p. 5247, 1995 DOI: 10.1016/0040-4039(95)00983-J

Enzyme inhibitor

This substituted pyridine (FW = 155.20 g/mol; CAS 939-23-1; M.P. = 69- 73°C; B.P. = 274-275°C), which occurs naturally and is likewise a manmade pollutant, inhibits human placental aromatase, Ki = 0.36 μM, monoamine oxidase, and NADH dehydrogenase. 4-Phenylpyridine is also an effective inhibitor of mitochondrial complex I. Note that it both occurs naturally and is an environmental pollutant.

4-Phenylpyridine(939-23-1)Related Product Information

• Chromium picolinate
• Triphenylphosphine
• Sulfasalazine
• 2-Phenylphenol
• 4-Methylpyridine
• 4-Dimethylaminopyridine
• BATHOPHENANTHROLINEDISULFONIC ACID DISODIUM SALT TRIHYDRATE
• 2,6-DIPHENYL-4-(2,4,6-TRIPHENYL-1-PYRIDINIO)PHENOLATE
• MPP+ IODIDE
• Bathophenanthroline
• PYRIDINITRIL
• 2,4,6-TRIPHENYLPYRIDINE
• BUFFER SOLUTION
• BATHOCUPROINEDISULFONIC ACID DISODIUM SALT
• CI 46045
• 4,4'-DIPHENYL-2,2'-BIPYRIDINE
• 4-Phenylpyridine-N-oxide
• o-Phenylpyridine,Phenylpyridine,95%