Basic information Safety Supplier Related

Diquafosol

Basic information Safety Supplier Related

Diquafosol Basic information

Product Name:
Diquafosol
Synonyms:
  • [[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-phosphinic acid
  • Diquafosol
  • Diquafosol [inn:ban]
  • Diquafosol [inn]
  • Kpy 998
  • p1,p4-Bis(5'-uridyl) tetrahydrogen tetraphosphate
  • Unii-7828vc80fj
  • P1,P4-Diuridine 5'-Tetraphosphate
CAS:
59985-21-6
MF:
C18H26N4O23P4
MW:
790.31
Product Categories:
  • Agonists
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
Mol File:
59985-21-6.mol
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Diquafosol Chemical Properties

Density 
2.044±0.06 g/cm3(Predicted)
storage temp. 
Store at 0-8 °C
solubility 
Water (Slightly)
pka
0.40±0.50(Predicted)
form 
Solid
color 
White to Pale Beige
Stability:
Hygroscopic
InChIKey
NMLMACJWHPHKGR-BTTIJRIRNA-N
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Diquafosol Usage And Synthesis

Uses

Diquafosol is a dinucleoside derivative of uridine that acts as a selective P2Y2 receptor agonist. Diquafosol is used as a therapeutic agent in the treatment of dry eye syndrome.

Definition

ChEBI: A pyrimidine ribonucleoside 5'-tetraphosphate compound having 5'-uridinyl residues at the P1- and P4-positions.

in vivo

Diquafosol (ophthalmic solution 3%; eyedrop, four times daily for 28 days) reduces intracellular ROS levels, apoptosis, and inflammation in rat[1].

Animal Model:6 weeks, 160-180 g Wistar female rats (dry eye model)[1]
Dosage:ophthalmic solution 3%
Administration:eyedrop, four times daily (8, 12 AM; 4, 8 PM) for 28 days
Result:Increased the expression of phospho-Erk1/2, phospho-Akt, and phospho-p90RSK, inhibits apoptosis, decreased the IL-1β, TNF-α expression.

IC 50

P2Y2 Receptor

DiquafosolSupplier

Shanghai Boyle Chemical Co., Ltd.
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Email
sales@boylechem.com
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Email
jkinfo@jkchemical.com
Chemsky (shanghai) International Co.,Ltd
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021-50135380
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shchemsky@sina.com
Nanjing Sunlida Biological Technology Co., Ltd.
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025-57798810
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sales@sunlidabio.com
Finetech Industry Limited
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027-87465837 19945049750
Email
sales@finetechnology-ind.com
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