Succinylsulfathiazole
Succinylsulfathiazole Basic information
- Product Name:
- Succinylsulfathiazole
- Synonyms:
-
- colistatin
- cremosuxidine
- kaoxidin
- KAOXIDINE
- sulfasuccidin
- sulfasuccidine
- sulfasuccinil
- sulfasuccithiazole
- CAS:
- 116-43-8
- MF:
- C13H13N3O5S2
- MW:
- 355.39
- EINECS:
- 204-141-0
- Product Categories:
-
- SULFASUXIDINE
- Antibacterial
- Antibiotics
- Antibiotics A to
- Antibiotics N-SAntibiotics
- Chemical Structure Class
- Antibiotics for Research and Experimental Use
- Biochemistry
- Sulfonamides (Antibiotics for Research and Experimental Use)
- Inhibits an EnzymeAntibiotics
- Interferes with DNA SynthesisSpectrum of Activity
- L - ZAntibiotics
- Mechanism of Action
- Sulfonamides
- Mol File:
- 116-43-8.mol
Succinylsulfathiazole Chemical Properties
- Melting point:
- 193.5°C
- Density
- 1.4807 (rough estimate)
- refractive index
- 1.6390 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 1 M NaOH: soluble50mg/mL
- pka
- pKa 4.5 (Uncertain)
- form
- powder
- color
- white to off-white
- Water Solubility
- 0.49g/L(38 ºC)
- λmax
- 282nm(H2O (pH 3.3 - 5))(lit.)
- Merck
- 14,8877
- BRN
- 349989
- CAS DataBase Reference
- 116-43-8(CAS DataBase Reference)
- EPA Substance Registry System
- Butanoic acid, 4-oxo-4-[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]- (116-43-8)
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 42/43
- Safety Statements
- 22-36/37-45
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- WM4767000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29350090
MSDS
- Language:English Provider:p-2-Thiazolylsulfamoylsuccinanilic acid
- Language:English Provider:SigmaAldrich
Succinylsulfathiazole Usage And Synthesis
Originator
Sulfasuxidine,MSD,US,1942
Uses
Succinylsulfathiazole is a sulfonamide antibiotic that was shown to inhibit bacteria that are responsible for folate production. Succinylsulfathiazole was used in various folate deficiency studies to block the synthesis of folic acid.
Uses
Succinylsulfathiazole is antibacterial
Definition
ChEBI: N-succinylsulfathiazole is a member of 1,3-thiazoles. It is functionally related to a sulfathiazole.
Manufacturing Process
3.92 g of succinic anhydride was added to a boiling suspension of 10 g of 2- sulfanilamidothiazole in 100 cc of alcohol. The mixture was then refluxed for five minutes after the addition was complete at which time all of the solids were in solution. The solution was then cooled and diluted with an equal volume of water. The white solid precipitate which formed was filtered and recrystallized from dilute alcohol, yielding 2-N4-succinylsulfanilamidothiazole, melting at 184°C to 186°C.
Therapeutic Function
Antibacterial (intestinal)
SuccinylsulfathiazoleSupplier
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Succinylsulfathiazole(116-43-8)Related Product Information
- Sulfanilamide
- Sulfathiazole
- N4-SUCCINYLSULFATHIAZOLE MONOHYDRATE
- N-METHYLSUCCINAMIC ACID
- 2-CHLOROMETHYL-3,4-DIMETHOXY PYRIDINE HYDROCHLORIDE
- 4-AMINO-N-METHYL-BENZENESULFONAMIDE
- 4-Acetamidobenzenesulfonamide
- 4-Acetamidothiophenol
- sulfasuccinamide
- 4-Anilino-4-oxobutanoic Acid
- 4-ETHYLAMINO-BENZENESULFONAMIDE
- Succinylsulfathiazole
- 4'-(thiazol-2-ylsulphamoyl)acetanilide