Succinylsulfathiazole Chemical Properties

Melting point:

193.5°C

Density 

1.4807 (rough estimate)

refractive index 

1.6390 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

1 M NaOH: soluble50mg/mL

pka

pKa 4.5 (Uncertain)

form 

powder

color 

white to off-white

Water Solubility 

0.49g/L(38 ºC)

λmax

282nm(H2O (pH 3.3 - 5))(lit.)

Merck 

14,8877

BRN 

349989

CAS DataBase Reference

116-43-8(CAS DataBase Reference)

EPA Substance Registry System

Butanoic acid, 4-oxo-4-[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]- (116-43-8)

Safety Information

Hazard Codes 

Xn

Risk Statements 

42/43

Safety Statements 

22-36/37-45

RIDADR 

3249

WGK Germany 

3

RTECS 

WM4767000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29350090

MSDS

• Language:English Provider:p-2-Thiazolylsulfamoylsuccinanilic acid
• Language:English Provider:SigmaAldrich

Succinylsulfathiazole Usage And Synthesis

Originator

Sulfasuxidine,MSD,US,1942

Uses

Succinylsulfathiazole is a sulfonamide antibiotic that was shown to inhibit bacteria that are responsible for folate production. Succinylsulfathiazole was used in various folate deficiency studies to block the synthesis of folic acid.

Uses

Succinylsulfathiazole is antibacterial

Definition

ChEBI: N-succinylsulfathiazole is a member of 1,3-thiazoles. It is functionally related to a sulfathiazole.

Manufacturing Process

3.92 g of succinic anhydride was added to a boiling suspension of 10 g of 2- sulfanilamidothiazole in 100 cc of alcohol. The mixture was then refluxed for five minutes after the addition was complete at which time all of the solids were in solution. The solution was then cooled and diluted with an equal volume of water. The white solid precipitate which formed was filtered and recrystallized from dilute alcohol, yielding 2-N4-succinylsulfanilamidothiazole, melting at 184°C to 186°C.

Therapeutic Function

Antibacterial (intestinal)

Description

Somatostatin Synthetic is a single, non-glycosylated polypeptide chain containing 14 amino acids, having a molecular mass of 1637.9 Dalton and a Molecular formula of C₇₆H₁₀₄N₁₈O₁₉S₂. The CAS# is 38916-34-6.

Background

Somatostatin (also known as growth hormone inhibiting hormone (GHIH) or somatotropin release-inhibiting hormone (SRIF) is a peptide hormone that regulates the endocrine systemand affects neurotransmission and cell proliferation via interaction with G-protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones. Somatostatin has two active forms produced by alternative cleavage of a single preproprotein: one of 14 amino acids, the other of 28 amino acids.

References

[1] Pharmaceutical Chemistry Journal, 1997, vol. 31, # 9, p. 471 - 473
[2] Patent: US2007/292352, 2007, A1. Location in patent: Page/Page column 45
[3] Patent: US2324013, 1941,
[4] Journal of the American Chemical Society, 1942, vol. 64, p. 1572,1573, 1574
[5] Patent: US2324014, 1941,

Succinylsulfathiazole(116-43-8)Related Product Information

• Sulfanilamide
• Sulfathiazole
• N4-SUCCINYLSULFATHIAZOLE MONOHYDRATE
• N-METHYLSUCCINAMIC ACID
• 2-CHLOROMETHYL-3,4-DIMETHOXY PYRIDINE HYDROCHLORIDE
• 4-AMINO-N-METHYL-BENZENESULFONAMIDE
• 4-Acetamidobenzenesulfonamide
• 4-Acetamidothiophenol
• sulfasuccinamide
• 4-Anilino-4-oxobutanoic Acid
• 4-ETHYLAMINO-BENZENESULFONAMIDE
• Succinylsulfathiazole
• 4'-(thiazol-2-ylsulphamoyl)acetanilide