Retinyl propionate Chemical Properties

Boiling point:

453.7±14.0 °C(Predicted)

Density 

0.963±0.06 g/cm3(Predicted)

vapor pressure 

0-0Pa at 20-96.2℃

Flash point:

128 °C

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)

form 

Oil

color 

Pale Yellow to Yellow

BRN 

2475675

Stability:

Light Sensitive

LogP

9.12 at 25℃

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

38-63-53-61

Safety Statements 

53-45

WGK Germany 

1

F 

1-8-10

MSDS

• Language:English Provider:SigmaAldrich

Retinyl propionate Usage And Synthesis

Suggestions for use

Usage levels of retinyl propionate in skin care range from 0.1–0.4%. It is often paired with niacinamide because this B vitamin enhances the stability and bioavailability of retinyl propionate.

Description

Retinyl propionate (RP) is a less well-known, but pretty interesting member of the retinoids, aka the "royal family of skincare".Similar to retinyl palmitate, retinyl Propionate is also a retinol ester with retinol and propionic acid being attached together.

Chemical Properties

Thick Yellow Oil

Uses

Retinyl Propionate is a Vitamin A ester derivative. Retinyl Propionate is a hypermitotic agent that is used in cosmetic formulations.This compound contains an unknown cis isomer.

Biochem/physiol Actions

Retinyl propionate, a derivative of retinol, is a fatty acid that is used as a sample preparation for copper-complexed collagen[1]. In metabolic processes, retinyl propionate is metabolized primarily into retinol (ROL) in the viable epidermis and dermis whereas ROL is esterified into retinyl palmitate (RPalm) and metabolized into the inactive retinoid 14‐hydroxy‐4,14‐retro‐retinol (14‐HRR)[2]. Retinol and its derivatives effectively intervene in the skin aging process. The matrix effect of retinyl propionate can be seen in the skin cells, bone cells, and cartilage tissue. Retinyl propionate has been shown to increase calcium pantothenate transport rates in human serum and also has a film-forming polymer effect.

Side effects

Side effects of using retinol may include: redness, irritation, burning, itching, dry skin, flaking and peeling of the skin, increased sensitivity to the sun, and skin cancer.

Structure and conformation

Retinyl propionate is closest in molecular size to pure retinoic acid with just three additional carbons. Vitamin A palmitate has an additional 16 carbons, making it too large to reach the dermis effectively.

References

[1] Wang Q, et al. The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging. Journal of Cosmetic Dermatology, 2023; 22: 2040-2049.
[2] Yang Y, et al. Hydrophobically modified inulin based nanoemulsions for enhanced stability and transdermal delivery of retinyl propionate. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022; 653: 129883.

Retinyl propionate(7069-42-3)Related Product Information

• Clobetasol propionate
• Betamethasone 17,21-dipropionate
• N-PENTYL PROPIONATE
• β-Carotene
• Riboflavin
• Vitamin B12
• D-Biotin
• Vitamin A palmitate
• Retinyl acetate
• Vitamin A
• RETINYL PALMITATE, [RETINOL 15-3H]
• axerophthene
• Retinyl propionate
• 2,4-HEXADIENYL PROPIONATE
• RETINYL PALMITATE, [PALMITATE-1-14C]
• TRANS,TRANS-2,4-HEXADIENYL ACETATE