5-Fluoro-2-hydroxypyridine Chemical Properties

Melting point:

150-155°C

Boiling point:

251.7±40.0 °C(Predicted)

Density 

1.26±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

10.09±0.10(Predicted)

form 

Crystalline Powder

color 

White to off-white

InChIKey

KLULSYPVWLJZAO-UHFFFAOYSA-N

CAS DataBase Reference

51173-05-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-37/38-41

Safety Statements 

26-39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29333999

5-Fluoro-2-hydroxypyridine Usage And Synthesis

Uses

5-Fluoro-2-hydroxypyridine is a halogenated compound used in the synthesis of 5-Fluoro-2-hydroxy-3-nitropyridine and 5-halogenated pyrimidine compounds.

Synthesis

5-Fluoro-2-hydroxypyridine is synthesised using 5-fluoro-2-methoxypyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
A total of 4.6 L of toluene solution containing 3-80 was placed in several sealed tubes and treated with 900 ml of 35percent HCl at 145° C. for 2 hr. LC/MS showed no starting material, only 4. The toluene solution was decanted and discarded. The aqueous phase was washed with EtOAc and concentrated down to remove volatiles to afford a brown solid containing the desired fluoro-hydroxypyridine 4-80. [1488] A total of 244 g of this solid was collected and taken to next step as is (it was not completely dry). [1489] Note: We have subsequently run this by decanting the toluene layer first prior to heating to reduce volumes. Same reaction was carried out using HBr (48percent in H2O) at 100° C. for 6 h with similar result to the literature procedure 49percent yield. [1490] Ref: J. Heterocyclic Chem., 10, 779, 1973 (for above Reactions, Including Analytical Data).

5-Fluoro-2-hydroxypyridine(51173-05-8)Related Product Information

• Sulfasalazine
• Chrysin
• Chromium picolinate
• Hydroxy silicone oil
• 2-Chloro-3-cyanopyridine
• 2-Hydroxypyridine
• 3-BROMO-5-FLUORO-2-METHOXYPYRIDINE
• 2,6-Dihydroxy-5-fluoro-3-cyanopyridine
• 5-FLUORO-2-METHOXYPYRIDINE-4-BORONIC ACID
• 5-FLUORO-2-HYDROXY-3-NITROPYRIDINE
• 4-BROMO-5-FLUORO-2-HYDROXY-3-NITROPYRIDINE
• 5-Fluoro-2-methoxynicotinic acid
• 5-Fluoro-2-methoxy-3-methylpyridine
• 2-Methoxy-5-fluoropyridine
• Fluorine
• 5-FLUORO-2-HYDROXYNICOTINIC ACID
• 5-FLUORO-2-METHOXY-6-PICOLINE
• 4-Pyridinecarboxaldehyde, 5-fluoro-1,2-dihydro-2-oxo- (9CI)