non A4 component of amyloid precursor, PARK1, PARK4, PD1, NACP (Non-a-beta component of Alzheimer disease amyloid, precursor) Chemical Properties

storage temp. 

-20°C

form 

lyophilized powder

biological source

human

Safety Information

WGK Germany 

WGK 2

Storage Class

10 - Combustible liquids

non A4 component of amyloid precursor, PARK1, PARK4, PD1, NACP (Non-a-beta component of Alzheimer disease amyloid, precursor) Usage And Synthesis

Uses

Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-γ. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

Biochem/physiol Actions

Among the familial mutations of α-synuclein in Parkinson′s disease, E46K has the greatest potential to aggregate. This mutation is a 188G-A tran-sition resulting in a Glu46-to-Lys (E46K) substitution in the amino-terminal region of the protein.

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