Lecirelin Chemical Properties

Density 

1.44

storage temp. 

Store at -20°C

solubility 

DMSO : 12.1 mg/mL (10.00 mM)

form 

Solid

pka

9.82±0.15(Predicted)

color 

White to off-white

InChIKey

XJWIEWPGHRSZJM-JUAATNMYNA-N

Lecirelin Usage And Synthesis

Uses

Mammalian LHRHa containing Supergestran was used to stimulate the spermiation of tench males. Half dose of lecirelin was almost equally effective to induce the disappearance of the dominant follicle at Day 6 to 7 of the estrous cycle in three GnRH analogs of cattle.

Definition

Lecirelin, a synthetic gonadotropin-releasing hormone (GnRH) analog, acts as a GnRH agonist. Lecirelin is widely used for the research of bovine ovarian follicular cysts. lecithin and buserelin, two nonapeptides, are used as the acetate. Lecirelin differs by substitution of D-tertiary leucine for glycine at position 6 and the replacement of glycine by ethylamide at position 10. Buserelin has a D-serine at position 6 and ethylamide at position 10.

in vitro

Lecirelin (2.07 μM) significantly increases the tension and frequency of contractions in preovulatory follicles (PF), small follicular cysts (FC-S), and large follicular cysts (FC-L). Lecirelin increases the strips from preovulatory follicles contract significantly more than strips from cysts.

References

[1] Picard-Hagen N, et al. Effect of gonadorelin, lecirelin, and buserelin on LH surge, ovulation, and progesterone in cattle. Theriogenology, 2015; 84: 177-183.

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