Tadalafil-d3 Chemical Properties

Melting point:

281-283°C

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly), DMSO (Slightly)

form 

Solid

color 

White to Off-White

Stability:

Unstable in Methanol

InChI

InChI=1/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21+/s3

InChIKey

WOXKDUGGOYFFRN-PDIFIXMTNA-N

SMILES

c12c3ccccc3nc1[C@H](c1cc3OCOc3cc1)N1C(=O)CN(C)C(=O)[C@H]1C2 |&1:9,27,r|

Tadalafil-d3 Usage And Synthesis

Description

Tadalafil-d₃ is intended for use as an internal standard for the quantification of tadalafil by GC- or LC-MS. Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC₅₀ = 1.2 nM). It is selective for PDE5 over PDE1-4 and 7-10 (IC₅₀s = 9.2-280 μM), however, it does also inhibit PDE11 (IC₅₀ = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury. It also reduces development of tobacco smoke-induced emphysema and pulmonary hypertension in mice. Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.

Chemical Properties

Tadalafil-d3 is White Solid

Uses

Tadalafil-d3 is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor. Intended for use as an internal standard for the quantification of Tadalafil by GC- or LC-mass spectrometry.

Uses

Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.

Tadalafil-d3(960226-55-5)Related Product Information

• N-Ethyl Tadalafil
• Tadalafil EP impurity E
• Tadalafil iMpurity D
• Tadalafil EP IMpurity F
• ent-Tadalafil
• tadalafi
• cis-ent-Tadalafil
• Tadalafil iMpurity C
• cis-Tadalafil
• (6R,trans)-6-(3,4-dihydroxyphenyl)-2,3,6,7,12,12a-hexahydro-2-Methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
• Tadalafil KetolactaM
• Tadalafil iMpurity E
• Tadalafil EP Impurity
• Tadalafil EP IMpurity G
• Tadalafil Spiro-urethane IMpurity
• [13C,2H3]-Tadalafil
• Tadalafil iMpurity I
• Tadalafil EP IMpurity A