3-Fluoro-2-nitropyridine Chemical Properties

Melting point:

35°C

Boiling point:

255.8±20.0 °C(Predicted)

Density 

1.439±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder to crystal

pka

-5.01±0.22(Predicted)

color 

Light yellow to Yellow to Orange

Water Solubility 

Slightly soluble in water.

InChI

InChI=1S/C5H3FN2O2/c6-4-2-1-3-7-5(4)8(9)10/h1-3H

InChIKey

IJVFHCSUEBAAOZ-UHFFFAOYSA-N

SMILES

C1([N+]([O-])=O)=NC=CC=C1F

CAS DataBase Reference

54231-35-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

34

Safety Statements 

36/37/39-45-24/25

RIDADR 

UN3261

TSCA 

N

HazardClass 

IRRITANT

HS Code 

29339900

3-Fluoro-2-nitropyridine Usage And Synthesis

Chemical Properties

light brown crystal powder or liquid

Uses

A specialty product for proteomics research applications.

Synthesis

A solution of sodium nitrite (20 g, 288 mmol) in water (40 mL) was added dropwise to a solution of 3-amino-2-nitropyridine (40 g, 288 ) in 34% fluoroboric acid (140 mL). mmol) in 34% fluoboric acid (140 mL) in a stirred mixture. The temperature was maintained between -8 ??C and -2 ??C during the addition. After 0.5 h, the suspension was filtered and the solid was washed with 34% fluoboric acid (35 mL), ether (80 mL), and dried at room temperature under high vacuum for 12 h to give 52 g of fluoroborate as an orange-brown solid salt. The dried solid is decomposed by heating to 120 ??C. After decomposition, the remaining oil was treated with a 10% sodium bicarbonate (80 mL) solution and the mixture was extracted with dichloromethane. The combined extracts were dried with sodium sulfate, filtered and the solvent removed under reduced pressure to give the title compound as a light yellow solid.

3-Fluoro-2-nitropyridine(54231-35-5)Related Product Information

• 3-Aminopyridine
• 2-Nitrocinnamic acid
• 2-NITROPYRIDINE
• 1,2,3-Trifluoro-4-nitrobenzene
• 3-Nitrotoluene
• 2-Chloro-3-cyanopyridine
• 5-CHLORO-2-FLUORO-3-NITROPYRIDINE
• 2-METHYL-4-PYRIDINEBORIC ACID HCL
• 2-AMINO-5-FLUORO-3-NITROPYRIDINE
• 2-hydroxy-5-fluoro-3-nitropyridine
• 4-FLUORO-3-NITROPYRIDINE
• 2-CHLORO-5-FLUORO-3-NITROPYRIDINE
• Fluorine
• 3-Fluoro-5-nitropyridine
• 2,4-DIBROMO-5-FLUORO-3-NITROPYRIDINE
• 2-CHLORO-3-FLUORO-4-NITROPYRIDINE N-OXIDE
• 2-FLUORO-4-NITROPYRIDINE,2-Fluoro-4-nitropyridine97%
• 3-FLUORO-4-NITROPYRIDINE-N-OXIDE