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Pyranoridine phosphate

Basic information Safety Supplier Related

Pyranoridine phosphate Basic information

Product Name:
Pyranoridine phosphate
Synonyms:
  • PYRANORIDINE TETRAPHOSPHATE
  • 4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pheno
  • phosphate(1:4)
  • pyranoridinephosphate
  • Pyranaridine tetraphosphate
  • 4-[(7-Chloro-2-methoxy-1,5-dihydropyrido[3,2-b]quinolin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one phosphate (1:4)
  • 2-Methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′-hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine tetraphosphate
  • 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one,phosphoricaci
CAS:
76748-86-2
MF:
C29H35ClN5O6P
MW:
616.05
Product Categories:
  • Inhibitor
Mol File:
76748-86-2.mol
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Pyranoridine phosphate Chemical Properties

Melting point:
233-236° (dec)
storage temp. 
2-8°C
solubility 
acetic acid: soluble5mg/mL
form 
solid
InChIKey
YKUQEKXHQFYULM-UHFFFAOYSA-N
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Safety Information

Hazard Codes 
Xn
Risk Statements 
63-22-41
Safety Statements 
26-36/37-39
WGK Germany 
2
RTECS 
SK4920000
Toxicity
LD50 in mice (mg/kg): 251 ±33 i.m.; 1368 ±239 orally (Shao)
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Pyranoridine phosphate Usage And Synthesis

Uses

Pyronaridine Phosphate is an antimalarial drug.

Biological Activity

pyronaridine (pnd), a synthetic quinolone derivative frequently prescribed for the treatment of malaria, is a selective and potent multidrug resistance (mdr) modulator of pgp-mediated mdr that inhibits the proliferation of a variety of tumor cells, including myeloid leukemia (k562 and k562/a02), epidermoid carcinoma (kb and kbv200), breast carcinoma (mcf-7 and mcf-7/adr), ovarian carcinoma (skov3, es-2 and pa-1), gastric carcinoma (bgc-823), colon carcinoma (lovo), hepatocellular carcinoma (smmz-7721 and qgy-7703), with the half maximal inhibition concentration ic50 values of 8.3 μm, 5.6 μm, 20.8 μm, 14.5 μm, 9.5 μm, 11 μm, 9.7 μm, 12.9 μm, 15.7 μm, 14.9 μm, 21.4 μm, 10.9 μm and 17.1 μm respectively [1].

References

[1] qi j, wang s, liu g, peng h, wang j, zhu z, yang c. pyronaridine, a novel modulator of p-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo. biochem biophys res commun. 2004 jul 9;319(4):1124-31.

Pyranoridine phosphateSupplier

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